Last Updated: May 20, 2026

Claims for Patent: 5,166,060

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Summary for Patent: 5,166,060

Title:	Process for the preparation of pyridine-2,3-dicarboxylic acids
Abstract:	Pyridine-2,3-dicarboxylic acids are prepared by the action of 2,3-dihydroxybenzoate-3,4-dioxygenase on 2,3-dihydroxybenzoic acids in a liquid medium which lacks active decarboxylase and which has a pH from 4 to 9, an ionic strength below about 1 molar, and a low concentration of metal cations and complex anions. In close temporal proximity, the 2-hydroxy-3-carboxymuconic acid semialdehyde which forms is allowed to react with a source of ammonia or a primary amine, avoiding substantial decarboxylation.
Inventor(s):	Randall A. Roehl, George W. Matcham, David I. Stirling
Assignee:	Celgene Corp
Application Number:	US07/332,339

Details for Patent 5,166,060

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Baxter Healthcare Corporation	ARTISS	fibrin sealant (human)	Solution	125266	March 19, 2008	5,166,060	2009-11-24
Baxter Healthcare Corporation	ARTISS	fibrin sealant (human)	For Solution	125266	March 19, 2008	5,166,060	2009-11-24
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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