Claims for Patent: 5,089,264

Summary for Patent: 5,089,264

Title:	Method for treatment of bovine retained placenta
Abstract:	A method and medicament for the treatment of bovine retained placenta membrane. The medicament comprises at least one proteolytic enzyme and in the preferred method, the medicament is administered via at least one of the blood vessels serving the umbilical cord of the host.
Inventor(s):	Eiler; Hugo (Knoxville, TN)
Assignee:	The University of Tennessee Research Corporation (Knoxville, TN)
Application Number:	07/515,452
Patent Claims:	1. A method for the treatment of a host bovine afflicted with retained placenta membrane comprising the administration to the host of an effective amount of at least one proteolytic enzyme selected from the group comprising collagenase, papain, pepsin and trypsin. 2. The method of claim 1 wherein said enzyme comprises a combination of effective enzymes. 3. The method of claim 1 wherein said enzyme comprises collagenase. 4. The method of claim 3 wherein said collagenase is derived from microorganisms. 5. The method of claim 4 wherein said microorganism is selected from the group comprising Vibrio algino lyticus, Achromobaceter iophagus/bacillum polymyxa, and Clostridium histolyticum. 6. The method of claim 1 wherein said enzyme is in solution and administered via injection into at least one of the blood vessels serving the umbilical cord. 7. The method of claim 6 wherein said one of the blood vessels is an artery. 8. The method of claim 1 wherein said effective amount of said enzyme is between about 1 and about 100,000 units. 9. The method of claim 1 wherein said effective amount of said enzyme is sufficient to effect substantial loosening of the attachment of cotyledons in said placenta from their associated caruncles within about 24 hours following injection of said enzyme. 10. A method for the treatment of bovine retained placenta membrane comprising the steps of identification of at least one of the blood vessels serving the umbilical cord of a host bovine, and injection into said blood vessel of an effective amount of a proteolytic enzyme selected from the group comprising collagenase, papain, pepsin, and trypsin. 11. The method of claim 10 wherein said method is performed postpartum. 12. The method of claim 10 wherein said identification and injection steps are carried out contemporaneously with dystocia or a Caesarean section conducted on said host.

Details for Patent 5,089,264

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Smith & Nephew, Inc.	SANTYL	collagenase	Ointment	101995	06/04/1965		2039-03-29