Claims for Patent: 5,045,315

Summary for Patent: 5,045,315

Title:	Process for treating thrombosis by administering poly-kringle plasminogen activator
Abstract:	Hybrid, third generation, plasminogen activators containing plural, heterologous polypeptide kringles prepared by recombinant DNA techniques as well as the genes coding for the activators, Vectors containing those genes and a method for using the plasminogen activators as thrombolytic agents, are disclosed.
Inventor(s):	Hung; Paul P. (Bryn Mawr, PA), Kalyan; Narender K. (King of Prussia, PA), Lee; Shaw-guang L. (Villanova, PA)
Assignee:	American Home Products Corporation (New York, NY)
Application Number:	07/601,542
Patent Claims:	1. A process for treating thrombosis in a mammal in need thereof which comprises administering into the vascular system of said mammal an effective amount of a human t-PA hybrid comprising at least both kringles of human t-PA and one or two heterologous kringles selected from the group consisting of the human urokinase kringle and either of the human prothrombin kringles. 2. A process of claim 1 in which said plasminogen activator is 91-(PTKaa.sup.65-248 -Ser-Glu-Gly-Asn-Ser-Asp)-92 t-PA. 3. The process of claim 1 in which said plasminogen activator is (UKaa.sup.1-131 -Ser-Glu-Gly-Asn-Ser-Asp)-.sup.1-91 t-PA. 4. The process of claim 1 in which said plasminogen activator is 91-(UKaa.sup.50-131 -Ser-Glu-Gly-Asn-Ser-Asp)-92 t-PA. 5. The process of claim 1 in which said plasminogen activator is 261-(Ser-Glu-Gly-Asn-Ser-Asp-UKaa.sup.50-131)-262 t-PA.

Details for Patent 5,045,315

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Microbix Biosystems Inc.	KINLYTIC	urokinase	For Injection	021846	January 16, 1978	5,045,315	2010-10-23