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Last Updated: December 30, 2025

Claims for Patent: 4,966,843

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Summary for Patent: 4,966,843

Title:	Expression of interferon genes in Chinese hamster ovary cells
Abstract:	DNA constructs are prepared which operably link human interferon genes, selective, eukaryotic marker genes, and promoter and expression control sequences for the expression of human interferon in Chinese hamster ovary (CHO) cells or progeny thereof. The human recombinant interferon so produced contains glycans which are a subset of the population of glycans which are contained in the native counterpart, and may be used in therapeutic formulations. The CHO cells yield high levels of human interferon with no detectable amounts of host IFN, either constitutive or inductive.
Inventor(s):	Francis P. McCormick, Michael A. Innis, Gordon M. Ringold
Assignee:	Berlex Laboratories Inc , Leland Stanford Junior University
Application Number:	US06/761,180

Details for Patent 4,966,843

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Emd Serono, Inc.	REBIF	interferon beta-1a	Injection	103780	March 07, 2002	4,966,843	2007-10-30
Emd Serono, Inc.	REBIF	interferon beta-1a	Injection	103780	December 17, 2004	4,966,843	2007-10-30
Emd Serono, Inc.	REBIF	interferon beta-1a	Injection	103780	December 21, 2012	4,966,843	2007-10-30
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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