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Last Updated: January 1, 2026

Claims for Patent: 4,687,738

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Summary for Patent: 4,687,738

Title:	Method for the production of HA fraction containing protective antigens of Bordetella pertussis and pertussis vaccine
Abstract:	A method for production of HA fraction containing protective antigens of Bordetella pertussis (i.e. a fraction containing F-HA and LPF-HA) in an industrial scale, for instance, with a fermentater, which comprises inoculating a strain of B. pertussis in a liquid culture containing a cyclodextrin or its derivative, culturing it by a spinner culture under controlling the culture temperature and the amount of dissolved oxygen and under defoaming condition, optionally under controlling the pH range, and harvesting the produced HA fraction from the culture broth at a stage of from logarithmic growth phase to static grow phase, and a method for production of a pertussis vaccine from the HA fraction thus obtained by formalinizing the HA fraction in the presence of an amino acid.
Inventor(s):	Akihiro Ginnaga, Hiroshi Koba, Shin Sakuma, Hisashi Kitagawa, Akira Yamada, Yoji Suzuki
Assignee:	Chemo Sero Therapeutic Research Institute Kaketsuken , Teijin Ltd
Application Number:	US06/874,670

Details for Patent 4,687,738

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Sanofi Pasteur Limited	QUADRACEL	diphtheria and tetanus toxoids and acellular pertussis adsorbed and inactivated poliovirus vaccine	Injection	125525	March 24, 2015	⤷ Get Started Free	2006-06-16
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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