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Last Updated: December 18, 2025

Claims for Patent: 4,540,573


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Summary for Patent: 4,540,573
Title:Undenatured virus-free biologically active protein derivatives
Abstract:A mammalian blood protein-containing composition such as whole blood, plasma, serum, plasma concentrate, cryoprecipitate, cryosupernatant, plasma fractionation precipitate or plasma fractionation supernatant substantially free of hepatitis and other lipid coated viruses with the yield of protein activity to total protein being at least 80% is disclosed. The protein-containing composition is contacted with di- or trialkylphosphate, preferably a mixture of trialkylphosphate and detergent, usually followed by removal of the di- or trialkylphosphate.
Inventor(s):Alexander R. Neurath, Bernard Horowitz
Assignee: New York Blood Center Inc
Application Number:US06/514,375

Details for Patent 4,540,573

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Csl Behring Llc MONOCLATE, MONOCLATE-P antihemophilic factor (human) For Injection 103953 May 14, 2003 ⤷  Get Started Free 2003-07-14
Csl Behring Llc MONOCLATE, MONOCLATE-P antihemophilic factor (human) For Injection 103953 March 04, 2004 ⤷  Get Started Free 2003-07-14
Octapharma Pharmazeutika Produktionsges.m.b.h. OCTAPLAS pooled plasma (human), solvent/detergent treated For Injection 125416 January 17, 2013 ⤷  Get Started Free 2003-07-14
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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