Claims for Patent: 4,315,998

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Summary for Patent: 4,315,998

Title:	Polymer-bound photosensitizing catalysts
Abstract:	Polymer-bound photosensitizing catalysts are effective in the heterogeneous catalysis of various photosensitized chemical reactions, such as photooxidation reactions, photodimerization reactions, and photocycloaddition reactions, and are thereafter readily separated from the reaction medium and reaction products by simple filtration. The polymer-bound photosensitizing catalysts comprise the nucleophilic displacement reaction product of (A) a polymeric material having attached thereto an available leaving group which is capable of being displaced in a nucleophilic displacement reaction with a nucleophilic reagent and (B) a photosensitizing catalytic compound containing in its molecule a nucleophile which is capable of displacing the leaving group attached to the polymeric material in a nucleophilic displacement reaction.
Inventor(s):	Neckers; Douglas C. (Bowling Green, OH), Blossey; Erich C. (Winter Park, FL), Schaap; A. Paul (Detroit, MI)
Assignee:	Research Corporation (New York, NY)
Application Number:	06/009,713
Patent Claims:	1. A method of preparing a polymer-bound photosensitizing catalyst for use in heterogeneous catalysis of photosensitized chemical reactions, which comprises forming a mixture in an organic solvent of a polymeric material having attached thereto an available leaving group which is capable of being displaced in a nucleophilic displacement reaction with a nucleophilic reagent and a photosensitizing catalytic compound containing in its molecule a nucleophile which is capable of displacing the chloride atom of a chloromethatylated styrene polymer in a nucleophilic displacement reaction and which nucleophile is a photosensitizer dye selected from the group consisting of rose bengal, acridine orange, chlorophyllin, crystal violet, eosin Y, fluoroscein, flavin mononucleotide, hematoporphyrin, hemin, malachite green, methylene blue, rhodamine B, chlorophyll, cosine, erythrosin, methylene green, toluidine blue and thionine, refluxing said mixture for a time sufficient to effect a nucleophilic displacement reaction between said chloromethylated styrene polymer and said photosensitizing dye, and recovering from said mixture the resulting polymer-bound photosensitizing catalyst beads. 2. The method of claim 1 wherein said polymeric material is a chloromethylated styrene polymer. 3. The method of claim 2, wherein said chloromethylated styrene polymer is a chloromethylated styrenedivinylbenzene copolymer. 4. The method of claim 1 wherein said polymeric material is a cross-linked poly(2-hydroxymethyl)methacrylateethylene glycol copolymer. 5. The method of claim 1 wherein said polymeric material is a polyvinyl formal copolymer. 6. The method of claim 1 wherein said polymeric material is a styrene-maleic anhydride copolymer. 7. The method of claim 1 wherein said photosensitizer dye is rose bengal. 8. The method of claim 1 wherein said photosensitizing catalytic compound is a parabenzoyl benzoic acid.

Details for Patent 4,315,998

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Recordati Rare Diseases, Inc.	PANHEMATIN	hemin for injection	For Injection	101246	July 20, 1983	4,315,998	1999-02-05