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Last Updated: December 16, 2025

Claims for Patent: 12,188,927

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Summary for Patent: 12,188,927

Title:	Methods and kits for predicting infusion reaction risk and antibody-mediated loss of response by monitoring serum uric acid during PEGylated uricase therapy
Abstract:	Methods and kits for predicting infusion reaction risk and antibody-mediated loss of response during intravenous PEGylated uricase therapy in gout patients is provided. Routine SUA monitoring can be used to identify patients receiving PEGylated uricase who may no longer benefit from treatment and who are at greater risk for infusion reactions.
Inventor(s):	Theresa Rosario-Jansen, David Erick Wright
Assignee:	Horizon Therapeutics USA Inc
Application Number:	US18/630,584

Details for Patent 12,188,927

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Horizon Therapeutics Ireland Dac	KRYSTEXXA	pegloticase	Injection	125293	September 14, 2010	12,188,927	2044-04-09
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

International Patent Family for US Patent 12,188,927

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Country	Patent Number	Estimated Expiration
World Intellectual Property Organization (WIPO)	2010151831	⤷ Get Started Free
World Intellectual Property Organization (WIPO)	2010151823	⤷ Get Started Free
United States of America	9377454	⤷ Get Started Free
United States of America	2025231181	⤷ Get Started Free
United States of America	2024255496	⤷ Get Started Free
United States of America	2023251247	⤷ Get Started Free
>Country	>Patent Number	>Estimated Expiration

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