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Last Updated: March 26, 2026

Claims for Patent: 12,049,652

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Summary for Patent: 12,049,652

Title:	PH20 polypeptide variants, formulations and uses thereof
Abstract:	Modified PH20 hyaluronidase polypeptides, including modified polypeptides that exhibit increased stability and/or increased activity, are provided. Also provided are compositions and formulations and uses thereof.
Inventor(s):	Ge Wei, H. Michael Shepard, Qiping Zhao, Robert James Connor
Assignee:	Halozyme Inc , Halozyme Therapeutics Inc
Application Number:	US18/064,886

Details for Patent 12,049,652

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Akorn, Inc.	HYDASE	hyaluronidase	Injection	021716	October 25, 2005	12,049,652	2042-12-12
Merck Sharp & Dohme Llc	KEYTRUDA	pembrolizumab	For Injection	125514	September 04, 2014	12,049,652	2042-12-12
Merck Sharp & Dohme Llc	KEYTRUDA	pembrolizumab	Injection	125514	January 15, 2015	12,049,652	2042-12-12
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

International Patent Family for US Patent 12,049,652

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Country	Patent Number	Estimated Expiration
World Intellectual Property Organization (WIPO)	2013102144	⤷ Start Trial
United States of America	9447401	⤷ Start Trial
United States of America	2025197836	⤷ Start Trial
United States of America	2025197835	⤷ Start Trial
United States of America	2025197834	⤷ Start Trial
United States of America	2025197833	⤷ Start Trial
>Country	>Patent Number	>Estimated Expiration

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