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Last Updated: December 16, 2025

Claims for Patent: 12,018,298

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Summary for Patent: 12,018,298

Title:	PH20 polypeptide variants, formulations and uses thereof
Abstract:	Modified PH20 hyaluronidase polypeptides, including modified polypeptides that exhibit increased stability and/or increased activity, are provided. Also provided are compositions and formulations and uses thereof.
Inventor(s):	Ge Wei, H. Michael Shepard, Qiping Zhao, Robert James Connor
Assignee:	Halozyme Inc , Halozyme Therapeutics Inc
Application Number:	US18/340,482

Details for Patent 12,018,298

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Akorn, Inc.	HYDASE	hyaluronidase	Injection	021716	October 25, 2005	⤷ Get Started Free	2043-06-23
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

International Patent Family for US Patent 12,018,298

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Country	Patent Number	Estimated Expiration
World Intellectual Property Organization (WIPO)	2013102144	⤷ Get Started Free
United States of America	9447401	⤷ Get Started Free
United States of America	2025197836	⤷ Get Started Free
United States of America	2025197835	⤷ Get Started Free
>Country	>Patent Number	>Estimated Expiration

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