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Last Updated: March 16, 2026

Claims for Patent: 11,773,177

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Summary for Patent: 11,773,177

Title:	Variant antibodies that bind OX40
Abstract:	The present disclosure provides variant anti-OX40 antibodies that mimic the activity of OX40L by behaving as an agonist against receptor OX40 to enhance T cell clonal expansion and differentiation. The variant anti-OX40 antibodies exhibit improved binding affinity for OX40 and improved agnostic activity, compared to a wild type anti-OX40 antibody (wild type 2B4 clone) from which the variant clones are derived. The variant anti-OX40 antibodies specifically bind OX40 receptors on activated T lymphocytes, stimulate proliferation of effector T cells, stimulate proliferation of effector T cells in the presence of regulatory T cells, and stimulate production of at least one cytokine from effector T cells.
Inventor(s):	Min Soo Kim
Assignee:	Vivasor Inc
Application Number:	US17/409,595

Details for Patent 11,773,177

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Takeda Pharmaceuticals U.s.a., Inc.	VONVENDI	von willebrand factor (recombinant)	For Injection	125577	December 08, 2015	11,773,177	2041-08-23
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

International Patent Family for US Patent 11,773,177

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Country	Patent Number	Estimated Expiration
United States of America	2021395380	⤷ Get Started Free
United States of America	2019169302	⤷ Get Started Free
United States of America	11142579	⤷ Get Started Free
>Country	>Patent Number	>Estimated Expiration

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