Last Updated: November 9, 2026

Claims for Patent: 11,666,606

Summary for Patent: 11,666,606

Title:	Methods of treating joint disease, disorders and conditions with tissue inhibitors of matrix metalloproteinases
Abstract:	Methods for treating joint diseases, disorders, and conditions, such as osteoarthritis, with a composition containing a therapeutically effective amount of tissue inhibitors of matrix metalloproteinases (TIMPs) are provided. The composition can contain TIMPs as part of amniotic fluid, or the TIMPs can be isolated from another source or recombinantly produced. The methods are particularly useful for treating osteoarthritis associated with degradation of articular cartilage by proteases. Also provided are methods of lubricating a joint, such as an osteoarthritic joint.
Inventor(s):	Jeffrey S. White, Robin R. Young
Assignee:	Prime Merger Sub LLC
Application Number:	US16/746,541

Details for Patent 11,666,606

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Modernatx, Inc.	SPIKEVAX	covid-19 vaccine, mrna	Injection	125752	January 31, 2022	⤷ Start Trial	2040-01-17
Modernatx, Inc.	SPIKEVAX	covid-19 vaccine, mrna	Injection	125752	September 11, 2023	⤷ Start Trial	2040-01-17
Modernatx, Inc.	SPIKEVAX	covid-19 vaccine, mrna	Injection	125752	July 9, 2025	⤷ Start Trial	2040-01-17
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

International Patent Family for US Patent 11,666,606

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Country	Patent Number	Estimated Expiration
United States of America	10576107	⤷ Start Trial
United States of America	12433918	⤷ Start Trial
United States of America	2016287641	⤷ Start Trial
United States of America	2020147144	⤷ Start Trial
United States of America	2024058391	⤷ Start Trial
>Country	>Patent Number	>Estimated Expiration

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