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Last Updated: January 1, 2026

Claims for Patent: 11,466,257

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Summary for Patent: 11,466,257

Title:	Cell-derived viral vaccines with low levels of residual cell DNA
Abstract:	The present invention relates to vaccine products for the treatment or prevention of viral infections. Further provided are methods of reducing contaminants associated with the preparation of cell culture vaccines. Residual functional cell culture DNA is degraded by treatment with a DNA alkylating agent, such as β-propiolactone (BPL), thereby providing a vaccine comprising immunogenic proteins derived from a virus propagated on cell culture, substantially free of residual functional cell culture DNA.
Inventor(s):	Jens-Peter Gregersen, Holger Kost
Assignee:	Seqirus UK Ltd
Application Number:	US16/843,940

Details for Patent 11,466,257

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Seqirus Inc.	AUDENZ	influenza a (h5n1) monovalent vaccine, adjuvanted	Injection	125692	January 31, 2020	⤷ Get Started Free	2040-04-09
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

International Patent Family for US Patent 11,466,257

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Country	Patent Number	Estimated Expiration
World Intellectual Property Organization (WIPO)	2007052163	⤷ Get Started Free
United States of America	2020377864	⤷ Get Started Free
United States of America	2009304729	⤷ Get Started Free
United States of America	10655108	⤷ Get Started Free
Slovenia	1951296	⤷ Get Started Free
>Country	>Patent Number	>Estimated Expiration

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