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Last Updated: December 31, 2025

Claims for Patent: 11,452,771

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Summary for Patent: 11,452,771

Title:	Scaffolded HIV-1 Env GP140 trimer immunogen
Abstract:	The present invention provides novel scaffolded HIV-1 vaccine immunogens. Some of the scaffolded immunogens contain a soluble gp140 trimer linked to the N-terminus of the nanoparticle subunit and a T-helper epitope that is fused via a short peptide spacer to the C-terminus of the nanoparticle subunit. Some other immunogens of the invention contain a soluble gp140 trimer protein that is linked to a stable nanoparticle via a short peptide spacer that is a T-helper epitope. Some of the scaffolded immunogens contain a gp140 trimer immunogen presented on a nanoparticle platform formed with I3-01 protein, E2p, or variants of protein 1VLW. Also provided in the invention are nucleic acids that encode the various vaccine immunogens described herein, and expression vectors and host cells harboring the nucleic acids. The invention further provides methods of using the scaffolded HIV-1 vaccine immunogens for preventing or treating HIV infections.
Inventor(s):	Jiang Zhu, Linling He
Assignee:	Scripps Research Institute
Application Number:	US17/021,821

Details for Patent 11,452,771

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Seqirus Inc.	AGRIFLU	influenza virus vaccine	Injection	125297	November 27, 2009	⤷ Get Started Free	2040-09-15
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

International Patent Family for US Patent 11,452,771

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Country	Patent Number	Estimated Expiration
World Intellectual Property Organization (WIPO)	2019089817	⤷ Get Started Free
United States of America	2023190910	⤷ Get Started Free
United States of America	2021030884	⤷ Get Started Free
United States of America	2019125890	⤷ Get Started Free
United States of America	10780178	⤷ Get Started Free
Japan	7730640	⤷ Get Started Free
Japan	2023156458	⤷ Get Started Free
>Country	>Patent Number	>Estimated Expiration

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