Claims for Patent: 11,180,749

Summary for Patent: 11,180,749

Title:	Allele-specific capture of nucleic acids
Abstract:	A method for separating a target allele from a mixture of nucleic acids by (a) providing a mixture of nucleic acids in fluidic contact with a stabilized ternary complex that is attached to a solid support, wherein the stabilized ternary complex includes a polymerase, primed nucleic acid template, and next correct nucleotide, wherein the template has a target allele, wherein the next correct nucleotide is a cognate nucleotide for the target allele, and wherein the stabilized ternary complex is attached to the solid support via a linkage between the polymerase and the solid support or via a linkage between the next correct nucleotide and the solid support; and (b) separating the solid support from the mixture of nucleic acids, thereby separating the target allele from the mixture of nucleic acids.
Inventor(s):	Corey M. DAMBACHER, Eugene Tu
Assignee:	Pacific Biosciences of California Inc
Application Number:	US16/535,009

Details for Patent 11,180,749

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Biomarin Pharmaceutical Inc.	VIMIZIM	elosulfase alfa	Injection	125460	February 14, 2014		2039-08-07

International Patent Family for US Patent 11,180,749

Country	Patent Number	Estimated Expiration
World Intellectual Property Organization (WIPO)	2018136117
United States of America	2019359975
United States of America	2018208922
United States of America	10415029