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Last Updated: December 18, 2025

Claims for Patent: 11,142,580

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Summary for Patent: 11,142,580

Title:	Oncolytic virus and method
Abstract:	An oncolytic virus (for example a replication competent virus) comprising a transgene cassette encoding an anti-CD40 antibody or binding fragment thereof, wherein the transgene cassette comprises an amino acid sequence given in SEQ ID NO: 12 or a sequence at least 95% identical thereto (such as 96, 97, 98 or 99% identical thereto), in particular a cassette of SEQ ID NO: 12; pharmaceutical compositions comprising the same, methods of preparing said oncolytic virus and compositions and use of the oncolytic virus or composition in treatment, in particular in the treatment of cancer. Also provided is the treatment of a patient population characterised as having a cancer expressing CD40, in particular a cancer over expressing CD40, with a therapy according to the present disclosure.
Inventor(s):	Champion Brian, Bromley Alice Claire Noel, Besneux Matthieu
Assignee:	PSIOXUS THERAPEUTICS LIMITED
Application Number:	US16618068
Patent Claims:

Details for Patent 11,142,580

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Amgen Inc.	IMLYGIC	talimogene laherparepvec	For Injection	125518	October 27, 2015	⤷ Get Started Free	2038-06-01
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

International Patent Family for US Patent 11,142,580

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Country	Patent Number	Estimated Expiration
South Africa	201907351	⤷ Get Started Free
World Intellectual Property Organization (WIPO)	2018220207	⤷ Get Started Free
United States of America	2020140563	⤷ Get Started Free
>Country	>Patent Number	>Estimated Expiration

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