Claims for Patent: 11,110,176

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Summary for Patent: 11,110,176

Title:	Composition and method for the protection of proteins, cell components and cells during temperature stress
Abstract:	Embodiments of the disclosure pertain to compositions containing (i) one or more non-antifreeze proteins or cell components or cells and (ii) one or more antifreeze proteins (AFPs), mimetics thereof, and/or analogs thereof, and a method of stabilizing a biologic (e.g., a protein, microbe, cell component or cell) against temperature stress and aggregation. The AFP may be selected from known antifreeze polypeptides and antifreeze peptides, analogs and mimetics of antifreeze proteins, active fragments of such antifreeze proteins, polypeptide and peptide mimetics, antifreeze peptoids and polymers, and combinations thereof. The non-antifreeze protein, cell component or cell comprises a known protein, cell component or cell used in the pharmaceutical, medical, agricultural, veterinary and/or food industry(ies). The AFP protects the function of the non-antifreeze protein, microbe(s), cell component(s) or cell(s) under temperature stress (e.g., a temperature of −20-60° C.).
Inventor(s):	Xin Wen
Assignee:	California State University Long Beach
Application Number:	US15/821,671
Patent Claims:

Details for Patent 11,110,176

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Discure Medical, Llc	CHYMODIACTIN	chymopapain	For Injection	018663	November 10, 1982	⤷ Get Started Free	2037-11-22
Discure Medical, Llc	CHYMODIACTIN	chymopapain	For Injection	018663	August 21, 1984	⤷ Get Started Free	2037-11-22
Thrombogenics Inc.	JETREA	ocriplasmin	Injection	125422	February 22, 2017	⤷ Get Started Free	2037-11-22
Thrombogenics Inc.	JETREA	ocriplasmin	Injection	125422	October 17, 2012	⤷ Get Started Free	2037-11-22
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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