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Last Updated: December 19, 2025

Claims for Patent: 11,090,333


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Summary for Patent: 11,090,333
Title:Immune stimulatory function and anti-tumor activity of TGF-β primed myeloid derived suppressor cells (MDSC)
Abstract:Embodiments of the disclosure concern methods and compositions related to cancer therapy using myeloid derived suppressor cells (MDSC) as a solo therapy or an adjunct therapy. The MDSCs are prepared by exposing bone marrow cells or blood cells to one or more compositions that induce their differentiation to MDSCs and also to TGF-β1, and in specific embodiments the exposure to TGF-β1 results in the MDSCs having anti-tumor activity and/or immune stimulatory activity.
Inventor(s):Andrew SIKORA, Padmini JAYARAMAN, Falguni PARIKH, Robin Parihar
Assignee: Baylor College of Medicine
Application Number:US15/759,717

Details for Patent 11,090,333

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Janssen Biotech, Inc. SIMPONI golimumab Injection 125289 April 24, 2009 ⤷  Get Started Free 2036-09-14
Janssen Biotech, Inc. SIMPONI golimumab Injection 125289 May 15, 2013 ⤷  Get Started Free 2036-09-14
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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