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Last Updated: December 16, 2025

Claims for Patent: 10,953,106

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Summary for Patent: 10,953,106

Title:	Antibodies
Abstract:	Antibodies having modified constant regions so as to permit conjugation of the antibody to a payload such as a therapeutic agent are described. Preferred antibodies include a mutation at light chain position 180 (positional numbering), most preferably the mutation is to a residue selected from C, K, Q, or a non-natural amino acid. Additional mutations may also be combined with a mutation at position 180; including one or more of light chain (LC) S208, LC S171, LC S182, LC A184, LC V191, LC S202, LC S203, LC T206, heavy chain (HC) S160, HC T190, HC S443, HC S447, HC S139, HC S168, HC V170, HC V176, HC T200, HC S445 according to a positional numbering convention.
Inventor(s):	Gomez De La Cuesta Ramon, Zurdo Jesús, Arnell Lars Arne Andreas, Ducry Laurent, Bonnafoux Laurence
Assignee:	LONZA LTD
Application Number:	US15550903
Patent Claims:

Details for Patent 10,953,106

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Janssen Biotech, Inc.	REOPRO	abciximab	Injection	103575	December 22, 1994	10,953,106	2036-02-15
Genentech, Inc.	RITUXAN	rituximab	Injection	103705	November 26, 1997	10,953,106	2036-02-15
Hoffmann-la Roche Inc.	ZENAPAX	daclizumab	Injection	103749	December 10, 1997	10,953,106	2036-02-15
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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