Claims for Patent: 10,953,099

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Summary for Patent: 10,953,099

Title:	Compositions comprising a metal source, dithiocarbamate and cyclodextrin
Abstract:	The present invention provides a novel class of dithiocarbamate-metal complexes and their uses in medicine. Also provided by the invention are combinations and pharmaceutical compositions, comprising a dithiocarbamate (or thiuram disulphide) such as disulfiram and cyclodextrin, with a source of a heavy metal. Surprisingly, the inventors found a synergistic potentiation of the anti-tumor effect, when a dithiocarbamate/heavy metal mixture was combined with a cyclodextrin. The compounds and combination of the invention are particularly useful in the treatment of tumor diseases, and other disorders. Provided are the compounds, combination, pharmaceutical compositions and kits, as well as methods for the preparation of the combinations of the invention.
Inventor(s):	Eberhard Amtmann, Nikolas Gunkel, Aubry MILLER, Michael MORGEN
Assignee:	Deutsches Krebsforschungszentrum DKFZ
Application Number:	US16/335,520

Details for Patent 10,953,099

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Kiniksa Pharmaceuticals (uk), Ltd.	ARCALYST	rilonacept	For Injection	125249	February 27, 2008	⤷ Start Trial	2037-10-13
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

International Patent Family for US Patent 10,953,099

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Country	Patent Number	Estimated Expiration
World Intellectual Property Organization (WIPO)	2018069525	⤷ Start Trial
United States of America	2019328886	⤷ Start Trial
Russian Federation	2019110876	⤷ Start Trial
Japan	2019536755	⤷ Start Trial
Spain	2911430	⤷ Start Trial
>Country	>Patent Number	>Estimated Expiration

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