Last Updated: July 27, 2026

Claims for Patent: 10,729,731

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Summary for Patent: 10,729,731

Title:	Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity
Abstract:	Bacterial strains are provided having at least one of a reduced size, a sialic acid coat, inducibly altered surface antigens, and expression of PD-L1 or CTLA-4 antagonists and/or tryptophanase. The bacteria may have improved serum half-life, increased penetration into tumors, increased tumor targeting and increased antitumor activity. The bacteria are useful for delivery of therapeutic agents that treat of neoplastic diseases including solid tumors and lymphomas.
Inventor(s):	David Gordon Bermudes
Assignee:	Individual
Application Number:	US16/659,168

Details for Patent 10,729,731

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Eli Lilly And Company	TALTZ	ixekizumab	Injection	125521	March 22, 2016	⤷ Start Trial	2039-10-21
Celgene Corporation, A Bristol-myers Squibb Company	ABECMA	idecabtagene vicleucel	Injection	125736	March 03, 2021	⤷ Start Trial	2039-10-21
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

International Patent Family for US Patent 10,729,731

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Country	Patent Number	Estimated Expiration
United States of America	9616114	⤷ Start Trial
United States of America	11813295	⤷ Start Trial
United States of America	11633435	⤷ Start Trial
United States of America	10828356	⤷ Start Trial
United States of America	10449237	⤷ Start Trial
United States of America	10286051	⤷ Start Trial
>Country	>Patent Number	>Estimated Expiration

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