Last Updated: September 24, 2026

Claims for Patent: 10,653,782

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Summary for Patent: 10,653,782

Title:	Retroviral particles expressing Sirt1 embedded within PPCN
Abstract:	Compositions and methods are provided for improved wound healing. In particular, provided herein are compositions and methods for the direct delivery of Sirtuin-1 (Sirt1) or vectors encoding Sirt1 to the wounds (e.g., of diabetic patients). In some embodiments, provided herein are therapeutic devices comprising: (a) a vector encoding Sirtuin-1 (Sirt 1); and (b) a hydrogel carrier. In some embodiments, the vector comprises a viral vector comprising a polynucleotide sequence encoding Sirt 1. In some embodiments, the vector comprises a non-viral vector comprising a polynucleotide sequence encoding Sirt1.
Inventor(s):	Guillermo A. Ameer, Michele Jen
Assignee:	NORTWESTERN UNIVERSITY , Northwestern University
Application Number:	US15/529,288

Details for Patent 10,653,782

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Seagen Inc.	ADCETRIS	brentuximab vedotin	For Injection	125388	19-Aug-11	⤷ Start Trial	2035-11-25
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

International Patent Family for US Patent 10,653,782

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Country	Patent Number	Estimated Expiration
United States of America	11529417	⤷ Start Trial
United States of America	2018303941	⤷ Start Trial
United States of America	2020384113	⤷ Start Trial
World Intellectual Property Organization (WIPO)	2016086088	⤷ Start Trial
>Country	>Patent Number	>Estimated Expiration

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