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Last Updated: March 27, 2026

Claims for Patent: 10,653,745

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Summary for Patent: 10,653,745

Title:	Treatment of rhinosinusitis with P-glycoprotein inhibitors
Abstract:	Provided herein are, inter alia, methods for treating rhinosinusitis with P-glycoprotein inhibitors. A subject having rhinosinusitis is identified and then treated by administration to the subject an effective amount of a P-gp inhibitor. The subject having rhinosinusitis can be identified by one of skill in the art based on known methods, e.g., based on detection of the presence of symptoms, by endoscopy, or by computed tomography. The efficacy of the treatment can be monitored by methods known in the art, e.g., by monitoring symptoms, by endoscopy or computed tomography. The P-glycoprotein inhibitor can be delivered to the subject's nasal passage and sinuses by an inhalation device, by flushing, by spraying, or by an eluting implant surgically placed in the subject's nasal passage or sinuses. The P-glycoprotein inhibitor can also be administered in combination with one or both of a corticosteroid and an antibiotic.
Inventor(s):	Benjamin S. Bleier
Assignee:	Massachusetts Eye and Ear
Application Number:	US15/687,074

Details for Patent 10,653,745

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Emergent Product Development Gaithersburg, Inc.	ACAM2000	smallpox (vaccinia) vaccine, live	For Injection	125158	August 31, 2007	⤷ Start Trial	2037-08-25
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

International Patent Family for US Patent 10,653,745

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Country	Patent Number	Estimated Expiration
World Intellectual Property Organization (WIPO)	2014106021	⤷ Start Trial
United States of America	9744210	⤷ Start Trial
United States of America	2024148823	⤷ Start Trial
>Country	>Patent Number	>Estimated Expiration

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