Last Updated: May 11, 2026

Claims for Patent: 10,646,549

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Summary for Patent: 10,646,549

Title:	Polynucleotides encoding interleukin-12 (IL12) and uses thereof
Abstract:	The present disclosure relates to polynucleotides comprising an open reading frame of linked nucleosides encoding human interleukin-12 (IL12), functional fragments thereof, and fusion proteins comprising IL12. In some embodiments, the open reading frame is sequence-optimized. In particular embodiments, the disclosure provides sequence-optimized polynucleotides comprising nucleotides encoding the polypeptide sequence of human IL12, or sequences having high sequence identity with those sequence optimized polynucleotides.
Inventor(s):	Joshua Frederick, Susannah HEWITT, Ailin Bai, Stephen Hoge, Vladimir Presnyak, Iain McFadyen, Kerry Benenato, Ellalahewage Sathyajith Kumarasinghe
Assignee:	ModernaTx Inc
Application Number:	US16/192,274

Details for Patent 10,646,549

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Novo Nordisk Inc.	XULTOPHY 100/3.6	insulin degludec and liraglutide	Injection	208583	November 21, 2016	10,646,549	2038-11-15
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

International Patent Family for US Patent 10,646,549

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Country	Patent Number	Estimated Expiration
World Intellectual Property Organization (WIPO)	2017201352	⤷ Start Trial
World Intellectual Property Organization (WIPO)	2017201350	⤷ Start Trial
World Intellectual Property Organization (WIPO)	2017201325	⤷ Start Trial
United States of America	2024024422	⤷ Start Trial
United States of America	2023346928	⤷ Start Trial
>Country	>Patent Number	>Estimated Expiration

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