Claims for Patent: 10,610,649

Summary for Patent: 10,610,649

Title:	Multiple dosage injector with rack and pinion dosage system
Abstract:	A dispensing mechanism for delivering a dosage of medicament including a housing, a push button, a crank arm that is slideably engageable with the push button, a ram, and a ratchet gear releasably engageable with the crank arm and ram, translation of the push button along an axis causing the crank arm to engage and rotate the ratchet gear which causes the ram to distally advance relative to the housing.
Inventor(s):	Madsen; Patrick (Litchfield, MN), Pflaumer; Hans (Roseville, MN), Swanson; Kevin (Plymouth, MN)
Assignee:	ANTARES PHARMA, INC. (Ewing, NJ)
Application Number:	15/650,332
Patent Claims:	1. A dispensing mechanism, comprising: a housing having a proximal-distal axis; a ram within the housing, movable in a distal direction; a user-operable push button moveable along the proximal-distal axis relative to the housing, the push button including a push button slot at a distal portion of the push button; a crank arm having a pawl tooth, a pivot point, and a crank arm engagement member slideably engageable with the push button slot such that movement of the push button causes the crank arm engagement member to move along the push button slot, causing rotation of the crank arm about the pivot point; and a ratchet gear having a first set of teeth releasably engageable with the pawl tooth and a second set of teeth releaseably engageable with the ram, wherein engagement of the pawl tooth with the first set of teeth of the ratchet gear causes the ratchet gear to rotate, causing the ram to distally advance relative to the housing, wherein the ram includes a first set of ram teeth configured to engage the second set of teeth on the ratchet gear and a second set of ram teeth configured to engage a housing protrusion to prevent movement of the ram in a proximal direction, and wherein the ram is rotationally fixed relative to the housing. 2. The dispensing mechanism of claim 1, further comprising an anti-reverse mechanism including: at least one housing ratchet integrally formed on an internal surface of the housing; and a flexible column extending from a distal portion of the push button, the flexible column having a flexible column protrusion at a proximal end thereof, wherein as the push button moves along the proximal-distal axis, the flexible column protrusion engages the housing ratchet and restricts movement of the push button to one direction during a resetting motion. 3. The dispensing mechanism of claim 2, wherein the flexible column protrusion is almond shaped. 4. The dispensing mechanism of claim 1, wherein at least one of the first set of teeth and the second set of teeth has involute spur rack geometry. 5. The dispensing mechanism of claim 1, wherein the housing protrusion is integrally formed within the housing. 6. The dispensing mechanism of claim 5, wherein first set of ram teeth and second set of teeth of the ratchet gear have similar corresponding involute gear teeth geometry. 7. The dispensing mechanism of claim 1, wherein the push button slot is oriented at an oblique angle with respect to the proximal-distal axis. 8. The dispensing mechanism of claim 1, wherein a push button slot has a portion that is oriented at an oblique angle with respect to the proximal-distal axis and a portion that oriented parallel to the proximal-distal axis. 9. The injector of claim 1, wherein the ratchet teeth of ratchet gear control the dose amount. 10. An injector comprising: the dispensing mechanism of claim 1; a cartridge disposed within the housing; a plunger disposed in the cartridge to seal a medicament therein, wherein the ram is associated with the plunger for forcing the plunger in a distal direction for ejecting a dose of medicament; and a needle in fluid communication with the cartridge for injecting the doses into a patient. 11. The injector of claim 10, wherein the medicament includes a parathyroid hormone. 12. The injector of claim 11, wherein the parathyroid hormone is teriparatide. 13. The injector of claim 10, wherein the medicament includes glucagon-like peptide receptor agonists. 14. The injector of claim 13, wherein the glucagon-like peptide receptor agonist is exenatide. 15. The injector of claim 13, wherein the glucagon-like peptide receptor agonist is liraglutide. 16. The injector of claim 1, wherein a first tooth of the second set of ram teeth is engaged with the housing protrusion and movement of the ram in the distal direction causes the first tooth of the second set of ram teeth to disengage from the housing protrusion and a second tooth of the second set of ram teeth to engage the housing protrusion to prevent movement of the ram in a proximal direction. 17. The injector of claim 1, wherein the ratchet gear rotates about a second axis, and the second axis is offset from the proximal-distal axis. 18. The injector of claim 1, wherein the first set of ram teeth and the second set of ram teeth are disposed on opposing sides of the proximal-distal axis.

Details for Patent 10,610,649

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Takeda Pharmaceuticals U.s.a., Inc.	NATPARA	parathyroid hormone	For Injection	125511	January 23, 2015	10,610,649	2037-07-14