Claims for Patent: 10,525,124

Summary for Patent: 10,525,124

Title:	Mixed allergen compositions and methods for using the same
Abstract:	Mixed allergen compositions of two or more different allergens are provided. In some instances, the mixed allergen compositions include: a nut allergen; an animal allergen; and at least one of: a non-nut plant allergen; a biotic agent; and a vitamin. Also provided are methods of administering the mixed allergen compositions to a subject. The mixed allergen compositions find use in a variety of applications, including health maintenance, immune balance, gut balance, immune support, health improvement and therapeutic applications.
Inventor(s):	Nadeau; Kari C. (Los Altos Hills, CA)
Assignee:	The Board of Trustees of the Leland Stanford Junior University (Stanford, CA)
Application Number:	16/171,874
Patent Claims:	1. A mixed allergen composition comprising: about 0.1% to about 15% by weight cashew complete allergen; about 0.1% to about 15% by weight walnut complete allergen; about 0.1% to about 15% by weight peanut complete allergen; about 0.1% to about 15% by weight hazelnut complete allergen; about 0.1% to about 15% by weight soy complete allergen; and about 0.1% to about 15% by weight salmon complete allergen; wherein the weight is per total mass of the mixed allergen composition. 2. The mixed allergen composition of claim 1, further comprising about 0.1% to about 15% by weight shrimp complete allergen. 3. The mixed allergen composition of claim 1, further comprising about 0.1% to about 15% by weight sesame complete allergen. 4. The mixed allergen composition of claim 1, further comprising about 0.1% to about 15% by weight crustacean complete allergen. 5. The mixed allergen composition of claim 3, further comprising about 0.1% to about 15% by weight crustacean complete allergen. 6. A unit formulation composition for oral administration comprising the mixed allergen composition of claim 1, and about 5% to about 95%, based on the weight of the total unit formulation composition, of a pharmaceutically acceptable carrier. 7. A unit formulation composition for oral administration comprising the mixed allergen composition of claim 5, and about 5% to about 95%, based on the weight of the total unit formulation composition, of a pharmaceutically acceptable carrier. 8. A unit formulation composition comprising a mixed allergen composition and a pharmaceutically acceptable carrier, wherein the mixed allergen composition comprises: about 15 mg to about 100 mg, by protein mass, peanut complete allergen; about 15 mg to about 100 mg, by protein mass, of one tree nut complete allergen; about 15 mg to about 100 mg, by protein mass, egg white complete allergen; and about 15 mg to about 100 mg, by protein mass, salmon complete allergen. 9. The unit formulation of claim 8, wherein the mixed allergen composition further comprises about 15 mg to about 100 mg, by protein mass, sesame complete allergen. 10. The unit formulation of claim 8, wherein the mixed allergen composition comprises about 15 mg to about 100 mg, by protein mass, shrimp complete allergen. 11. The unit formulation of claim 8, wherein the one tree nut complete allergen is almond complete allergen. 12. The unit formulation of claim 11, further comprising one or more additional tree nut complete allergens. 13. The unit formulation of claim 12, wherein the one or more additional tree nut complete allergens are each selected from the group consisting of walnut complete allergen, hazelnut complete allergen, pecan complete allergen, cashew complete allergen, pistachio complete allergen, and combinations thereof. 14. The unit formulation of claim 12, where the unit formulation comprises about 15 mg to about 100 mg, by protein mass, of each additional tree nut complete allergen. 15. The unit formulation of claim 13, where the unit formulation comprises about 15 mg to about 100 mg, by protein mass, of each of: walnut complete allergen, hazelnut complete allergen, and pecan complete allergen. 16. The unit formulation of claim 8, wherein the mixed allergen composition further comprises about 15 mg to about 100 mg, by protein mass, pistachio complete allergen. 17. The unit formulation of claim 7, wherein the unit formulation composition has a total mass of 2 grams to 5 grams. 18. The unit formulation of claim 7, wherein the mixed allergen composition comprises 10 or more different allergens. 19. The unit formulation of claim 16, wherein the unit formulation comprises about 5% to about 95% by weight of the pharmaceutically acceptable carrier. 20. A pharmaceutically acceptable mixed allergen composition comprising: about 0.1% to about 15% by weight walnut complete allergen; about 0.1% to about 15% by weight peanut complete allergen; about 0.1% to about 15% by weight hazelnut complete allergen; about 0.1% to about 15% by weight soy complete allergen; about 0.1% to about 15% by weight salmon complete allergen; about 0.1% to about 15% by weight wheat complete allergen; about 0.1% to about 15% by weight crustacean complete allergen; and a pharmaceutically acceptable carrier. 21. A unit formulation composition comprising a mixed allergen composition and a pharmaceutically acceptable carrier, wherein the mixed allergen composition comprises: about 15 mg to about 100 mg, by protein mass, peanut complete allergen; about 15 mg to about 100 mg, by protein mass, of one tree nut complete allergen; about 15 mg to about 100 mg, by protein mass, egg white complete allergen; and about 15 mg to about 100 mg, by protein mass, pistachio complete allergen; and fish complete allergen or crustacean complete allergen.

Details for Patent 10,525,124

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Aimmune Therapeutics, Inc.	PALFORZIA	peanut (arachis hypogaea) allergen powder-dnfp	Powder	125696	January 31, 2020		2038-10-26