Claims for Patent: 10,457,711

Summary for Patent: 10,457,711

Title:	Dermatophagoides farinae protein
Abstract:	Provided are a novel Dermatophagoides farinae protein, and a diagnostic drug, a prophylactic drug and a therapeutic drug for an allergic disease caused by Dermatophagoides farinae. A Dermatophagoides farinae protein selected from the group consisting of the following (a) to (c), or a fragment peptide thereof: (a) a protein including an amino acid sequence set forth in SEQ ID NO:2; (b) a protein including an amino acid sequence in which one or several amino acids have been substituted, deleted, or added relative to the amino acid sequence set forth in SEQ ID NO:2, and having allergenicity of Dermatophagoides farinae; and (c) a protein including an amino acid sequence having 90% or higher identity with the amino acid sequence set forth in SEQ ID NO:2, and having allergenicity of Dermatophagoides farinae.
Inventor(s):	Asaka; Naomasa (Tsukuba, JP), Tanaka; Yuki (Tsukuba, JP), Inagaki; Naoki (Gifu, JP)
Assignee:	TAIHO PHARMACEUTICAL CO., LTD. (Chiyoda-ku, JP)
Application Number:	15/532,256
Patent Claims:	1. A method for preventing or treating an allergic disease caused by Dermatophagoides farinae, the method comprising administering a Dermatophagoides farinae protein selected from the group consisting of (a), (b) and (c) below, or a fragment peptide comprising 10 to 34 amino acid residues of (a), (b) or (c) below, to a patient in need thereof: (a) a protein comprising the amino acid sequence of SEQ ID NO:2; (b) a protein comprising an amino acid sequence in which one to ten amino acids have been substituted or deleted, and/or one or several amino acids have been added, relative to the amino acid sequence of SEQ ID NO:2, and having allergenicity of Dermatophagoides farina; and (c) a protein comprising an amino acid sequence having 90% or higher identity with the amino acid sequence of SEQ ID NO:2, and having allergenicity of Dermatophagoides farinae. 2. A method for detecting an allergic disease caused by Dermatophagoides farinae, the method comprising administering a Dermatophagoides farinae protein selected from the group consisting of (a), (b) and (c) below, or a fragment peptide comprising 10 to 34 amino acid residues of (a), (b) or (c) below, to a test subject in need thereof, and measuring an allergic state of the test subject: (a) a protein comprising the amino acid sequence of SEQ ID NO:2; (b) a protein comprising an amino acid sequence in which one to ten amino acids have been substituted or deleted, and/or one or several amino acids have been added, relative to the amino acid sequence of SEQ ID NO:2, and having allergenicity of Dermatophagoides farinae; and (c) a protein comprising an amino acid sequence having 90% or higher identity with the amino acid sequence of SEQ ID NO:2, and having allergenicity of Dermatophagoides farina. 3. The method of claim 1, wherein (a) is administered to the patient. 4. The method of claim 1, wherein (b) is administered to the patient. 5. The method of claim 1, wherein (c) is administered to the patient. 6. The method of claim 1, wherein the fragment peptide comprising 10 to 34 amino acid residues of (a), (b) or (c) is administered to the patient. 7. The method of claim 2, wherein (a) is administered to the test subject. 8. The method of claim 2, wherein (b) is administered to the test subject. 9. The method of claim 2, wherein (c) is administered to the test subject. 10. The method of claim 2, wherein the fragment peptide comprising 10 to 34 amino acid residues of (a), (b) or (c) is administered to the test subject.

Details for Patent 10,457,711

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Greer Laboratories, Inc.	N/A	insects (whole body), mite dermatophagoides farinae	Injection	101834	09/15/1958		2034-12-02