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Last Updated: April 18, 2024

Claims for Patent: 10,450,613

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Summary for Patent: 10,450,613

Title:	EGFR/NEDD9/TGF-.beta. interactome and methods of use thereof for the identification of agents having efficacy in the treatment of hyperproliferative disorders
Abstract:	Compositions and methods for the treatment and diagnosis of cancer are disclosed.
Inventor(s):	Astsaturov; Igor (Philadelphia, PA), Golemis; Erica A. (Oreland, PA), Serebriiskii; Ilya G. (Rockledge, PA), Weiner; Louis M. (Washington, DC)
Assignee:	Fox Chase Cancer Center (Philadelphia, PA)
Application Number:	15/171,663
Patent Claims:	1. A method for modulating sensitivity to EGFR/MEK-1 targeting agents in cancer cells, comprising: a) providing cancer cells comprising genes present in an EGFR/NEDD9/TGF-.beta. interactome, said genes being involved in cellular proliferation and EGFR/MEK-1 signalling; b) contacting said cancer cells with at least one compound which inhibits EGFR/NEDD9/TGF-.beta. interactome gene SC4MOL; and c) contacting said cancer cells of step b) with at least one EGFR-MEK-1 targeting agent which is selected from erlotinib, and cetuximab, thereby increasing sensitivity to said EGFR/MEK-1 targeting agent in said cancer cells, wherein said cancer cells are squamous cell carcinoma cells. 2. The method of claim 1, wherein said compound is a siRNA that decreases SC4MOL expression.

Details for Patent 10,450,613

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Eli Lilly And Company	ERBITUX	cetuximab	Injection	125084	02/12/2004	⤷ Try a Trial	2027-11-09
Eli Lilly And Company	ERBITUX	cetuximab	Injection	125084	03/28/2007	⤷ Try a Trial	2027-11-09
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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