Claims for Patent: 10,413,530

Summary for Patent: 10,413,530

Title:	Pharmaceutical composition containing the tromethamine salt of L-ampicillin
Abstract:	A method for increasing the number of CD4+ T-lymphocytes in the serum of a subject in need of such treatment comprising administering to the subject a pharmaceutical composition comprising an amount of an L-isomer of .beta.-lactam effective to increase the number of CD4+ T-lymphocytes in said patient\'s serum.
Inventor(s):	Bristow; Cynthia L. (Long Beach, NY), Winston; Ronald H. (Santa Barbara, CA)
Assignee:	Alpha-1 Biologics, LLC (Stony Brook, NY)
Application Number:	15/874,694
Patent Claims:	1. A pharmaceutical composition of matter comprising the tromethamine salt of L-ampicillin. 2. The pharmaceutical composition of claim 1 comprising the tromethamine salt of L-ampicillin and a pharmaceutically acceptable carrier, excipient, or diluent, wherein said L-ampicillin has substantially no bactericidal activity. 3. The pharmaceutical composition of claim 2 wherein said carrier is selected from the group consisting of water, aqueous saline solutions, aqueous dextrose and glycerol solutions. 4. The pharmaceutical composition of claim 2 wherein said carrier is a solid dosage form carrier, selected from the group consisting of a binder, a glidant, an encapsulating agent, a flavorant, and a colorant. 5. The pharmaceutical composition of claim 2 wherein said carrier is an oil selected from the group consisting of peanut oil, soybean oil, mineral oil and sesame oil. 6. The pharmaceutical formulation of claim 2 wherein said pharmaceutically acceptable salt is formed with a cation selected from the group consisting of benzathine, tcalcium, cholinate, diethanolamine, diethylamine, lysine, magnesium, meglumine, piperazine, potassium, procaine, silver, sodium, tromethamine and zinc. 7. The pharmaceutical formulation of claim 2 wherein said pharmaceutically acceptable salt is formed with an anion selected from the group consisting of acetate, benzoate, besylate, bromide, camphorsulfonate, chloride, chlortheophyllinate, citrate, ethandisulfonate, fumarate, gluceptate, gluconate, glucuronate, hippurate, iodide, isethionate, lactate, lactobionate, laurylsulfate, malate, maleate, mesylate, methylsulfate, naphthoate, napsylate, nitrate, octadecenoate, oleate, oxalate, pamoate, phosphate, polygalacturonate, succinate, sulfate, sulfosalicylate, tartrate, tosylate and trifluoroacetate. 8. The pharmaceutical formulation of claim 6 wherein said pharmaceutically acceptable salt is the tromethamine salt.

Details for Patent 10,413,530

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Aimmune Therapeutics, Inc.	PALFORZIA	peanut (arachis hypogaea) allergen powder-dnfp	Powder	125696	January 31, 2020	10,413,530	2038-01-18