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Last Updated: December 18, 2025

Claims for Patent: 10,398,734

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Summary for Patent: 10,398,734

Title:	Processes for production of tumor infiltrating lymphocytes and uses of same in immunotherapy
Abstract:	The present invention provides improved and/or shortened methods for expanding TILs and producing therapeutic populations of TILs, including novel methods for expanding TIL populations in a closed system that lead to improved efficacy, improved phenotype, and increased metabolic health of the TILs in a shorter time period, while allowing for reduced microbial contamination as well as decreased costs. Such TILs find use in therapeutic treatment regimens.
Inventor(s):	Seth Wardell, James Bender, Michael T. Lotze
Assignee:	Iovance Biotherapeutics Inc
Application Number:	US16/201,957

Details for Patent 10,398,734

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Iovance Biotherapeutics, Inc.	AMTAGVI	lifileucel	Suspension	125773	February 16, 2024	10,398,734	2038-11-27
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

International Patent Family for US Patent 10,398,734

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Country	Patent Number	Estimated Expiration
World Intellectual Property Organization (WIPO)	2019190579	⤷ Get Started Free
World Intellectual Property Organization (WIPO)	2018182817	⤷ Get Started Free
United States of America	2025121009	⤷ Get Started Free
United States of America	2025121008	⤷ Get Started Free
United States of America	2025082683	⤷ Get Started Free
>Country	>Patent Number	>Estimated Expiration

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