Claims for Patent: 10,390,753

Summary for Patent: 10,390,753

Title:	Blister strip
Abstract:	A blister strip which can be stuck onto the skin, is formed from at least two sheets and has an applicator for applying a medium contained in the blister to the skin, wherein the blister strip includes an upper sheet, with at least one protuberance, wherein the underside of the upper sheet, the underside enclosing the protuberance, is of adhesive configuration. The blister strip has a lower sheet, which covers the lower surface of the blister strip and can be drawn off from the adhesive underside of the upper sheet. The protuberance contains an applicator, separating the protuberance into at least two sub-volumes. Wherein the applicator has at least one opening, which connects two sub-volumes, wherein one sub-volume is located between the applicator and the lower sheet, and wherein at least one sub-volume is entirely surrounded by the inner surface of the protuberance and the applicator, and contains the medium.
Inventor(s):	Forstner; Bernhard (Linz, AT)
Assignee:	ALLTEST GmbH (Linz, AT)
Application Number:	15/520,988
Patent Claims:	1. A blister strip which can be stuck onto skin and is formed from at least two films and comprises at least one applicator for applying a medium contained in a blister and the substances contained in the medium onto or into the skin, wherein the blister strip comprises an upper film which has at least one protuberance, wherein the lower side of the upper film, which lower side surrounds each protuberance, is designed so as to be adhesive, and the blister strip comprises a lower film which covers the lower surface of the blister strip and can be pulled off from the adhesive lower side of the upper film, wherein: in at least one protuberance of the upper film one applicator is located, said applicator is located between first and second partial volumes of the protuberance, the first partial volume of the protuberance is located between the applicator and the lower film, the second partial volume of the protuberance is located between the top surface of the protuberance and the applicator and contains the medium, each applicator has at least one opening which connects the first and the second partial volumes, and said opening is sealed in the unopened state of the blister strip to separate said first partial volume and said second partial volume of the protuberance from each other in a sealed manner. 2. The blister strip as claimed in claim 1, wherein the upper film is a laminate consisting of a plurality of films. 3. The blister strip as claimed in claim 1, wherein the protuberance is a dome-shaped, dimensionally stable and plastically deformable dome. 4. The blister strip as claimed in, claim 1, wherein said opening is sealed by a thin membrane. 5. The blister strip as claimed in claim 1, wherein a sealing stopper closes the opening of the applicator. 6. The blister strip as claimed in claim 5, wherein the sealing stopper is adhesively bonded to the lower film, or is formed by a protuberance of the lower film. 7. The blister strip as claimed in claim 5, wherein the sealing stopper closes the entire area of the protuberance of the upper film. 8. The blister strip as claimed in claim 1, wherein the applicator is disk-shaped and is connected all the way around at the edge of the disk to the inner wall of the protuberance, wherein, in the center of the disk, the applicator has an applicator point which projects from the disk in the direction of the lower film, wherein, in the applicator point, at least one opening runs through the applicator. 9. The blister strip as claimed in claim 8, wherein the applicator point has one or more central openings, wherein, annularly around the opening, sharp or pointed elements point from the applicator point in the direction of the lower film or the skin. 10. The blister strip as claimed in claim 1, wherein the applicator has at least one pointed or sharp element which can be brought into contact with the skin. 11. The blister strip as claimed in claim 6, wherein the applicator is adhesively bonded or welded to or compressed with the upper film. 12. The blister strip as claimed in claim 6, wherein the edge of the applicator has a structured design, and the upper film is pressed in a form-fitting manner into said structure. 13. The blister strip as claimed in claim 8, wherein the edge region of the disk of the applicator is designed to be wider than the region of the disk between the edge and the applicator point. 14. The blister strip as claimed in claim 8, wherein the applicator is inserted into the protuberance in such a manner that the lower edge of the disk lies spaced apart from the adhesive lower side of the upper film. 15. The blister strip as claimed in claim 6, wherein the upper film is composed of a plastically deformable material. 16. The blister strip as claimed in claim 6, wherein the applicator is a dimensionally stable body and is formed from hard plastic. 17. The blister strip as claimed in claim 6, wherein a venting opening is present in that partial volume of the protuberance which does not contain the medium, wherein the venting opening leads into the surroundings and is closeable, or opens into a sealed expandable volume. 18. The blister strip as claimed in claim 6, wherein the medium is a liquid that contains an allergen. 19. The blister strip as claimed in claim 18, wherein the blister strip has a plurality of blisters, wherein each blister contains a medium, wherein one only contains the medium, one additionally contains histamine, and there are any desired number of blisters with distinguishable allergens. 20. The blister strip as claimed in claim 1, wherein: the upper foil comprises multiple protuberances that are spaced to each other, the lower side of the upper film, which lower side surrounding each protuberance, comprises an adhesive, one applicator is inserted in each of multiple protuberances of the upper film, in each of said multiple protuberances: one applicator is located between two partial volumes of said protuberance, a first partial volume of said protuberance lies between the applicator and the lower film, and a second partial volume of said protuberance is located between the top surface of said protuberance and the applicator and contains the medium, the applicator has at least one opening which connects two partial volumes, which opening is sealed in the unopened state of the blister strip to separate said first partial volume and said second partial volume of said protuberance from each other in a sealed manner, at least the medium of one protuberance contains a first allergen, and the medium of a further protuberance is selected from the group of: medium containing histamine; medium without allergen; medium that contains a second allergen. 21. A blister strip adapted to adhere to skin, comprising: an upper film including at least one protuberance, the at least one protuberance including at least a first partial volume and a second partial volume, a lower side of the upper film surrounding the protuberance and adapted to be adhesive; a lower film covering a lower surface of the blister strip and adapted to be detached from the lower side of the upper film; and at least one applicator for applying onto or into the skin a medium contained in a blister of the blister strip formed by the protuberance, the medium including substances, the at least one applicator being located in the at least one protuberance of the upper film and between the first and second partial volumes, the applicator including at least one opening adapted to connect the first and the second partial volumes when the blister strip is in an opened state, the first partial volume being located between the applicator and the lower film, the second partial volume being located between a top surface of the protuberance and the applicator and containing the medium; wherein the at least one opening is sealed in an unopened state of the blister strip to separate the first partial volume and the second partial volume from each other in a sealed manner.

Details for Patent 10,390,753

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Jubilant Hollisterstier Llc	N/A	positive skin test control-histamine	Injection	103891	March 13, 1924		2035-10-16