Last Updated: May 11, 2026

Claims for Patent: 10,307,481

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Summary for Patent: 10,307,481

Title:	CD37 immunotherapeutics and uses thereof
Abstract:	The present invention generally provides methods for B-cell reduction in an individual using CD37-specific binding molecules. In particular, the invention provides methods for B-cell reduction using CD37-specific binding molecules alone, or a combination of CD37-specific binding molecules and CD20-specific binding molecules, in some instances a synergistic combination. The invention further provides materials and methods for treatment of diseases involving aberrant B-cell activity. In addition, the invention provides humanized CD37-specific binding molecules.
Inventor(s):	Laura S. Grosmaire, Martha S. Hayden-Ledbetter, Jeffrey A. Ledbetter, Peter A. Thompson, Sandy A. Simon, William Brady
Assignee:	Aptevo Research and Development LLC
Application Number:	US11/493,132

Details for Patent 10,307,481

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Novo Nordisk Inc.	XULTOPHY 100/3.6	insulin degludec and liraglutide	Injection	208583	November 21, 2016	10,307,481	2026-07-25
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

International Patent Family for US Patent 10,307,481

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Country	Patent Number	Estimated Expiration
South Africa	200800692	⤷ Start Trial
World Intellectual Property Organization (WIPO)	2007014278	⤷ Start Trial
United States of America	2019290755	⤷ Start Trial
United States of America	2014072562	⤷ Start Trial
United States of America	2014010813	⤷ Start Trial
United States of America	2014004117	⤷ Start Trial
>Country	>Patent Number	>Estimated Expiration

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