Claims for Patent: 10,307,467

Summary for Patent: 10,307,467

Title:	Use of hyaluronidase for treatment of muscle stiffness
Abstract:	Provided are methods and kits for reducing the severity of muscle stiffness. The method comprises delivering to one or more specific locations in the deep fascia of an affected muscle a composition comprising a therapeutically effective amount of hyaluronidase.
Inventor(s):	Raghavan; Preeti (Brooklyn, NY), Stecco; Antonio (Padua, IT)
Assignee:	New York University (New York, NY)
Application Number:	15/325,938
Patent Claims:	1. A method for providing relief from stiffness of a first muscle in an individual comprising the steps of delivering in a region of deep fascia surrounding the first muscle or in a region of deep fascia surrounding a second muscle that affects the function of the first muscle at or near one or more centers of coordination or center of fusion associated with the first muscle, second muscle or a combination thereof, a composition comprising a therapeutically effective amount of hyaluronidase, wherein a center of coordination or center of fusion is characterized by slidable layers in the deep fascia, and wherein delivering the composition results in reduction of stiffness of the first muscle. 2. The method of claim 1, wherein hyaluronidase is administered via injections at multiple centers of coordination. 3. The method of claim 2, wherein the amount of hyaluronidase for each injection is about 25 to 300 USP units. 4. The method of claim 2, wherein the hyaluronidase injections are carried out at 2-6 CC locations. 5. The method of claim 2, wherein hyaluronidase injections are carried out at 6-10 CC locations. 6. The method of claim 2, wherein the hyaluronidase injections are repeated over a period of between 1-12 months.

Details for Patent 10,307,467

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Bausch & Lomb Incorporated	VITRASE	hyaluronidase	Injection	021640	May 05, 2004	10,307,467	2035-07-16
Bausch & Lomb Incorporated	VITRASE	hyaluronidase	Injection	021640	December 02, 2004	10,307,467	2035-07-16
Amphastar Pharmaceuticals, Inc.	AMPHADASE	hyaluronidase	Injection	021665	October 26, 2004	10,307,467	2035-07-16
Akorn, Inc.	HYDASE	hyaluronidase	Injection	021716	October 25, 2005	10,307,467	2035-07-16

International Patent Family for US Patent 10,307,467

Country	Patent Number	Estimated Expiration
World Intellectual Property Organization (WIPO)	2016011262
United States of America	2019282674
United States of America	2017202930
United States of America	11654185
European Patent Office	3169351