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Last Updated: December 16, 2025

Claims for Patent: 10,280,409

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Summary for Patent: 10,280,409

Title:	Codon optimized polynucleotide for high level expression of CRM197
Abstract:	The present invention relates to high level expression of bacterial toxoid or toxin protein of pharmacological interest by means of an optimized novel polynucleotide sequence and host transformed with the said polynucleotide. Specifically, the invention provides a method for high production of polypeptide CRM197 wherein, the polynucleotide of the invention is used to transform a suitable host resulting in over-expression of corresponding proteins and a method for isolating the expressed polypeptide. More particularly, the present invention relates to high level expression of CRM197 in Escherichia coli and a method for the isolation and purification thereof.
Inventor(s):	Akshay Goel, Ravi Pratap Narayan Mishra, Narender Dev Mantena, Mahima Datla
Assignee:	Biological E Ltd
Application Number:	US15/523,616

Details for Patent 10,280,409

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Glaxosmithkline Biologicals	MENVEO	meningococcal (groups a, c, y, and w-135) oligosaccharide diphtheria crm197 conjugate vaccine	Injection	125300	February 19, 2010	⤷ Get Started Free	2035-11-17
Glaxosmithkline Biologicals	MENVEO	meningococcal (groups a, c, y, and w-135) oligosaccharide diphtheria crm197 conjugate vaccine	Injection	125300	October 14, 2022	⤷ Get Started Free	2035-11-17
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

International Patent Family for US Patent 10,280,409

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Country	Patent Number	Estimated Expiration
South Africa	201703150	⤷ Get Started Free
World Intellectual Property Organization (WIPO)	2016079755	⤷ Get Started Free
United States of America	2017306302	⤷ Get Started Free
Saudi Arabia	517381488	⤷ Get Started Free
Mexico	388191	⤷ Get Started Free
Mexico	2017006506	⤷ Get Started Free
>Country	>Patent Number	>Estimated Expiration

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