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Last Updated: December 29, 2025

Claims for Patent: 10,245,328

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Summary for Patent: 10,245,328

Title:	Gadolinium complex comprising DO3A-tranexamic acid conjugate
Abstract:	The present disclosure relates to a magnetic resonance imaging (MRI) contrast agent containing a gadolinium complex, and more specically, to a DO3A-tranexamic acid compound having a structure of a chemical formula 1, or an ester compound thereof, and gadolinium complexes thereof. The DO3A-tranexamic acid compound or the ester compound thereof may be used to prepare gadolinium complexes. The gadolinium complexes exhibit thermodynamic and kinetic stabilities, and show the relaxation rate equal to that of the clinical contrast agent which is currently commercially available. Therefore, the gadolinium complexes can be widely used as an MRI contrast agent.
Inventor(s):	Tae-Jeong Kim, Yong Min Chang
Assignee:	Industry Academic Cooperation Foundation of KNU
Application Number:	US15/110,386

Details for Patent 10,245,328

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Auxilium Pharmaceuticals, Inc.	XIAFLEX	collagenase clostridium histolyticum	For Injection	125338	February 02, 2010	10,245,328	2035-01-08
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

International Patent Family for US Patent 10,245,328

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Country	Patent Number	Estimated Expiration
World Intellectual Property Organization (WIPO)	2015105352	⤷ Get Started Free
United States of America	2016331849	⤷ Get Started Free
South Korea	20150083721	⤷ Get Started Free
South Korea	101603699	⤷ Get Started Free
Japan	6246378	⤷ Get Started Free
Japan	2017502072	⤷ Get Started Free
European Patent Office	3093285	⤷ Get Started Free
>Country	>Patent Number	>Estimated Expiration

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