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Last Updated: March 28, 2024

Claims for Patent: 10,159,763


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Summary for Patent: 10,159,763
Title:Method for producing alpha-calcium sulfate hemihydrate bone graft
Abstract: The present invention discloses a method for producing the alpha-calcium sulfate hemihydrate bone graft, which comprises the following steps: mixing calcium sulfate dihydrate and deionized water to produce calcium sulfate dihydrate paste; stirring and heating the calcium sulfate dihydrate paste at least 160.degree. C. within 100-350 psi to produce the conversion calcium sulfate hemihydrate, filtering the conversion calcium sulfate hemihydrate with high temperature to produce the filtered calcium sulfate hemihydrate, and washing the filtered calcium sulfate hemihydrate by absolute alcohol to get the alpha-calcium sulfate hemihydrate bone graft. The present invention does not use any catalyst, possesses a high purity, high mechanical strength, and good biocompatibility, facilitates bone growth and angiogenesis, requires only 31.degree. C., the highest temperature, during the curing process. It makes the present invention more secure in the biomedical applications.
Inventor(s): Ou; Keng-Liang (New Taipei, TW), Yu; Chih-Hua (New Taipei, TW), Chan; Yu-Hao (New Taipei, TW), Cheng; Wei-Jen (New Taipei, TW)
Assignee: 3D GLOBAL BIOTECH INC. (New Taipei, TW)
Application Number:15/644,673
Patent Claims:1. A method for producing an alpha-calcium sulfate hemihydrate bone graft, comprising the following steps of: S1: mixing calcium sulfate dihydrate and pure water to produce a calcium sulfate dihydrate paste; S2: stirring and heating the calcium sulfate dihydrate paste to at least 160.degree. C. for producing a conversion calcium sulfate hemihydrate; S3: filtering the conversion calcium sulfate hemihydrate with a high temperature to produce a filtered calcium sulfate hemihydrate; and S4: washing the filtered calcium sulfate hemihydrate by an absolute alcohol to generate the alpha-calcium sulfate hemihydrate bone graft.

2. The method of claim 1, wherein the step S.sub.2 is for stirring the calcium sulfate dihydrate paste by a magnetic stir bar.

3. The method of claim 1, wherein the step S.sub.2 is for heating the calcium sulfate dihydrate paste to 160.degree. C. and then maintaining at the temperature for 10 minutes to produce the conversion calcium sulfate hemihydrate.

4. The method of claim 3, wherein the step S.sub.2 is for heating the calcium sulfate dihydrate paste to 160.degree. C. in 20 minutes and then maintaining at the temperature for 10 minutes to produce the conversion calcium sulfate hemihydrate.

5. The method of claim 1, wherein the pure water is sterile water or de-ionized water.

6. The method of claim 1, wherein the step S.sub.2 is executed in a Teflon.TM. tube.

7. The method of claim 6, wherein a tube pressure in the Teflon.TM. tube is between 100 psi and 350 psi.

8. The method of claim 1, wherein, in the step of S.sub.3, the high temperature for filtering the conversion calcium sulfate hemihydrate is over than 100.degree. C.

9. The method of claim 1, further comprising the following step of: S.sub.5: drying the alpha-calcium sulfate hemihydrate bone graft.

10. The method of claim 9, wherein the step S.sub.5 is for drying the alpha-calcium sulfate hemihydrate bone graft at 60.degree. C. to 80.degree. C. for 6 hours to 8 hours.

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