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Last Updated: December 17, 2025

Claims for Patent: 10,125,172

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Summary for Patent: 10,125,172

Title:	Conformationally stabilized RSV pre-fusion F proteins
Abstract:	In some embodiments, the present invention provides respiratory syncytial virus (RSV) F proteins, polypeptides and protein complexes that comprise one or more cross-links to stabilize the protein, polypeptide or protein complex in its pre-fusion conformation. In some embodiments the present invention provides RSV F proteins, polypeptides and protein complexes comprising one or more mutations to facilitate such cross-linking. In some embodiments the present invention provides compositions comprising such proteins, polypeptides or protein complexes, including vaccine compositions, and methods of making and using the same.
Inventor(s):	Christopher Patrick Marshall, Jason Scott McLellan, Peter Joseph Alff, Claudio Bertuccioli, Roberto Mariani
Assignee:	Calder Biosciences Inc , US Department of Health and Human Services
Application Number:	US14/340,519

Details for Patent 10,125,172

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Pfizer Inc.	ABRYSVO	respiratory syncytial virus vaccine	Injection	125769	May 31, 2023	⤷ Get Started Free	2034-07-24
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

International Patent Family for US Patent 10,125,172

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Country	Patent Number	Estimated Expiration
World Intellectual Property Organization (WIPO)	2015013551	⤷ Get Started Free
United States of America	2025171500	⤷ Get Started Free
United States of America	2022119454	⤷ Get Started Free
United States of America	2019292228	⤷ Get Started Free
United States of America	2015030622	⤷ Get Started Free
United States of America	11993633	⤷ Get Started Free
Japan	6685903	⤷ Get Started Free
>Country	>Patent Number	>Estimated Expiration

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