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Last Updated: March 26, 2026

Claims for Patent: 10,112,994

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Summary for Patent: 10,112,994

Title:	Methods of producing two chain proteins in bacteria
Abstract:	Provided herein are methods of producing a polypeptide containing two chains, such as an antibody including a light chain and a heavy chain. In particular, methods are provided for producing heterologous secretory proteins in bacteria through utilization of optimized expression vectors and culture processes.
Inventor(s):	Giulianotti James, Reilly Dorothea
Assignee:	GENENTECH, INC.
Application Number:	US14934100

Details for Patent 10,112,994

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Genentech, Inc.	LUCENTIS	ranibizumab	Injection	125156	June 30, 2006	10,112,994	2035-11-05
Genentech, Inc.	LUCENTIS	ranibizumab	Injection	125156	August 10, 2012	10,112,994	2035-11-05
Genentech, Inc.	LUCENTIS	ranibizumab	Injection	125156	October 13, 2016	10,112,994	2035-11-05
Genentech, Inc.	LUCENTIS	ranibizumab	Injection	125156	March 20, 2018	10,112,994	2035-11-05
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

International Patent Family for US Patent 10,112,994

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Country	Patent Number	Estimated Expiration
World Intellectual Property Organization (WIPO)	2016073791	⤷ Start Trial
United States of America	2019112368	⤷ Start Trial
United States of America	2016159898	⤷ Start Trial
United States of America	11299539	⤷ Start Trial
Russian Federation	2705274	⤷ Start Trial
Russian Federation	2017119403	⤷ Start Trial
Mexico	384534	⤷ Start Trial
>Country	>Patent Number	>Estimated Expiration

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