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Last Updated: December 28, 2025

Claims for Patent: 10,052,382


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Summary for Patent: 10,052,382
Title:Methods for using antibodies for 3′ iso-LM1 and 3′, 6′-iso-LD1tumor gangliosides
Abstract:High affinity antibodies were made to gangliosides expressed on tumor cells. The antibodies can be used analytically, diagnostically, therapeutically, and theranostically. The antibodies may be used to target cytotoxic reagents to tumor cells, thus minimizing full-body toxicity. The antibodies may also be used with out added cytotoxin. The antibodies may be detectably labeled or labelable for analytic and diagnostic purposes. The combination of specificity and affinity of the antibodies render them particularly useful.
Inventor(s):Darell Bigner, Chien-Tsun Kuan, Ira H. Pastan, Hailan Piao
Assignee: UNITED STATES GOVERNMENT HEALTH AND HUMAN SERVICES (NIH), Secretary of, Department of , United States, Health (nih), Secretary of , Duke University
Application Number:US15/171,018

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