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Last Updated: May 5, 2024

Claims for Patent: 10,039,758

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Summary for Patent: 10,039,758

Title:	Compositions and methods for inhibiting bacterial and viral pathogens
Abstract:	Compositions and methods including Amodiaquine (AQ) or N-Desethy Amodiaquine (DEAQ) are provided for treating, inhibiting, or preventing cathepsin B dependent pathogens and toxins in a host cell or infected subject. Compositions and methods also include AQ or DEAQ in combination with an antibiotic for more effective clearance of the pathogen and/or toxins.
Inventor(s):	Martchenko; Mikhail (Claremont, CA), Zilbermintz; Leeor (Encino, CA), Leonardi; William (Rosemead, CA)
Assignee:	Keck Graduate Institute of Applied Life Sciences (Claremont, CA)
Application Number:	14/922,114
Patent Claims:	1. A method of inhibiting Bacillus anthracis in a host cell or in a subject, the method comprising; administering Amodiaquine (AQ) or N-Desethyl Amodiaquine (DEAQ) to the host cell or the subject. 2. The method of claim 1, wherein the AQ or DEAQ is administered at a dose of about 4.2 uM to about 70 uM or about 1.5 mg/kg to about 10.0 mg/kg based on the weight of the subject. 3. The method of claim 1, further comprising administering an antibiotic. 4. The method of claim 3, wherein the antibiotic is selected from the group consisting of Octodrine, vancomycin, clindamycin, cephaloridine, fidaxomicin, metronidazole, ciprofloxacin, doxycycline, erythromycin, penicillin, tetracycline, and combinations thereof. 5. The method of claim 3, wherein the antibiotic comprises Octodrine. 6. The method of claim 3, wherein the antibiotic and the AQ or DEAQ are administered as a mixture. 7. The method of claim 5, wherein the AQ or DEAQ is administered at a dose of about 1.5 mg/kg to about 10.0 mg/kg and the Octodrine is administered at a dose of about 1.5 mg/kg to about 50 mg/kg based on the weight of the subject.

Details for Patent 10,039,758

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Emergent Biodefense Operations Lansing Llc	BIOTHRAX	anthrax vaccine adsorbed	Injection	103821	11/12/1998	⤷ Try a Trial	2034-10-24
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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