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Last Updated: December 18, 2025

Claims for Patent: 10,034,948


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Summary for Patent: 10,034,948
Title:Low molecular weight polyethylene glycol drug conjugates having improved drug biological activity
Abstract:Provided are polyethylene glycol drug conjugates of general formula (I), (II) or (III) and pharmaceutical compositions and a use thereof. The conjugates are formed by combining low molecular weight polyethylene glycol with 2-4 drug molecules. The conjugates can interact with receptor dimers or polymers, thereby improving the in vivo distribution of the drug, changing the oil and water distribution coefficient, enhancing the pharmacological activity, reducing the blood-brain barrier permeability of the drug, and improving the bioavailability of the drug.
Inventor(s):Lihua Xu, Xuan Zhao, Zewang Feng, Jinliang Wang, Zhen'guo WANG
Assignee: Jenkem Technology Co Ltd Tianjin Branch , Jenkem Technology Co Ltd
Application Number:US15/700,057

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