Claims for Patent: 10,034,462

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Summary for Patent: 10,034,462

Title:	Animal model of nash-induced hepatocellular carcinoma and methods for developing specific therapeutics
Abstract:	The invention provides a non-human animal model for non-alcoholic steatohepatitis (NASH)-induced heptocellular carcinoma, methods of screening for agents for treating heptocellular carcinoma, methods of screening for targets useful in suppressing NASH progression to heptocellular carcinoma, methods of treating heptocellular carcinoma, and compositions for treating the same.
Inventor(s):	Karin; Michael (La Jolla, CA), Umemura; Atsushi (Kyoto, JP), Nakagawa; Hayato (Tokyo, JP)
Assignee:	The Regents of the University of California (Oakland, CA)
Application Number:	15/178,935
Patent Claims:	1. A method of inducing hepatocellular carcinoma (HCC) or HCC-like symptoms in a transgenic mouse comprising transplanting HCC progenitor cells (HcPCs) into a transgenic mouse and subjecting the transgenic mouse to a high fat diet (HFD), wherein the transgenic mouse comprises major urinary protein-urokinase plasminogen activator (MUP-uPA) gene. 2. The method of claim 1, wherein the transgenic mouse exhibits elevated expression or activity of p62, NRF2, mTORC1, or c-Myc, as compared to non-transgenic wild-type control mice. 3. The method of claim 1, wherein the transgenic mouse exhibits increased expression of type 1 collagen al mRNA, as compared to a non-transgenic wild-type control mouse. 4. The method of claim 1, wherein the transgenic mouse exhibits increased hepatocyte ballooning, serum alanine aminotransferase, liver triglycerides (TG) and cholesterol, as compared to a non-transgenic wild-type control mouse.

Details for Patent 10,034,462

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Microbix Biosystems Inc.	KINLYTIC	urokinase	For Injection	021846	January 16, 1978	10,034,462	2036-06-10
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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