Claims for Patent: 10,016,492

Summary for Patent: 10,016,492

Title:	Methods for extracting a tooth
Abstract:	Methods of extracting teeth involving contacting, prior to extraction, the tissue surrounding a tooth to be extracted with a composition providing an agent capable of destroying the periodontal ligament surrounding the tooth, such as, collagenase.
Inventor(s):	Marynka Kalmani; Keren (Ramat Hasharon, IL), Weinberg; Evgeny (Herzliya, IL), Gafni; Yosef (Jerusalem, IL)
Assignee:	PROTEOLEASE LTD. (Ramat Hasharon, IL)
Application Number:	14/527,487
Patent Claims:	1. A method for extracting a tooth in a subject in need thereof, the method comprising: injecting into the tissue surrounding said tooth a composition comprising collagenase; applying, after 0.25 to 3 hours, an extraction force parallel to the long axis of said tooth; and extracting said tooth. 2. The method of claim 1, wherein the composition is contacted with at least one locus at the periodontal ligament space surrounding the tooth. 3. The method of claim 1, wherein said collagenase is selected from the group consisting of collagenase I, collagenase II, collagenase III and a combination thereof. 4. The method of claim 3, wherein said composition comprises 1 to 1 mass ratio of collagenase I to collagenase II. 5. The method of claim 1, wherein said composition has an effective volume of 0.01 to 3 ml. 6. The method of claim 1, wherein said composition further comprises an agent, selected from the group consisting of: a painkiller, an anesthetic, an antibiotic, a vitamin, a growth factor, a flavoring agent and combination thereof. 7. A method for extracting a tooth in a subject in need thereof, the method comprising: injecting into the tissue surrounding said tooth a composition comprising synthetic collagenase; applying, after 0.25 to 3 hours, an extraction force parallel to the long axis of said tooth; extracting said tooth; and placing a dental implant at a cavity obtained following the step of extracting said tooth. 8. The method of claim 7, wherein the composition is contacted with at least one locus at the periodontal ligament space surrounding the tooth. 9. The method of claim 7, wherein said synthetic collagenase is selected from the group consisting of synthetic collagenase I, synthetic collagenase II, synthetic collagenase III and a combination thereof. 10. The method of claim 9, wherein said composition comprises 1 to 1 mass ratio of synthetic collagenase I to synthetic collagenase II. 11. The method of claim 7, wherein said composition has an effective volume of 0.01 to 3 ml. 12. The method of claim 7, wherein said composition further comprises an agent, selected from the group consisting of: a painkiller, an anesthetic, an antibiotic, a vitamin, a growth factor, a flavoring agent and combination thereof. 13. A method for extracting a tooth in a subject in need thereof, the method comprising: injecting into the tissue surrounding said tooth a composition consisting of collagenase; applying, after 0.25 to 3 hours, an extraction force parallel to the long axis of said tooth; and extracting said tooth. 14. The method of claim 13, wherein the composition is contacted with at least one locus at the periodontal ligament space surrounding the tooth. 15. The method of claim 13, wherein said collagenase is selected from the group consisting of collagenase I, collagenase II, collagenase III and a combination thereof. 16. The method of claim 15, wherein said composition comprises 1 to 1 mass ratio of collagenase I to collagenase II. 17. The method of claim 13, wherein said composition has an effective volume of 0.01 to 3 ml.

Details for Patent 10,016,492

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Smith & Nephew, Inc.	SANTYL	collagenase	Ointment	101995	06/04/1965		2039-02-26