➤ Get the DrugPatentWatch Daily Briefing

Get Daily Updates on Generic Entry, Litigation, Biosimilars, and more …

Serving leading biopharmaceutical companies globally:

McKinsey
Boehringer Ingelheim
Moodys
Johnson and Johnson
Baxter
Harvard Business School

Last Updated: October 16, 2021

DrugPatentWatch Database Preview

Claims for Patent: 10,004,742

➤ Get the DrugPatentWatch Daily Briefing

« Back to Dashboard

Summary for Patent: 10,004,742
Title:Method of treating cancer
Abstract: Methods are provided of treating a human for cancer comprising administering at least one dose of lapatinib, or a pharmaceutically acceptable salt or composition thereof, to a patient, wherein said patient does not have one or more allelic polymorphisms selected from the group of: HLA-DQA1*0201, HLA-DQB1*0202, and HLA-DRB1*0701. Patients may also be free of genotypes in TNXB; rs12153855 and/or rs17207923.
Inventor(s): Bing; Nan (Research Triangle Park, NC), Briley; Linda Perry (Research Triangle Park, NC), Parham; Laura R. (Research Triangle Park, NC), Cox; Charles J. (Stevenage, GB), Spraggs; Colin F. (Stevenage, GB)
Assignee: Novartis AG (Basel, CH)
Application Number:15/356,719
Patent Claims:1. A method of treating a human for breast cancer comprising: (a) obtaining a biological sample from said human; (b) detecting whether an allelic polymorphism at HLA-DRB1*0701 is present in said biological sample; (c) determining that said human does not have an allelic polymorphism at HLA-DRB1*0701 based on detecting the absence of said allelic polymorphism in step (b); and (d) administering at least one dose of lapatinib or a pharmaceutically acceptable salt or composition thereof to said human, thereby treating the human for breast cancer.

2. The method according to claim 1, wherein lapatinib, or a pharmaceutically acceptable salt or composition thereof, is administered to said human as monotherapy.

3. The method according to claim 1, wherein said lapatinib, or a pharmaceutically acceptable salt or composition thereof, is co-administered with at least one other anti-cancer agent.

4. The method according to claim 3, wherein said at least one other anti-cancer agent is selected from the group of: trastuzumab, capecitabine, paclitaxel, carboplatin, pazopanib and letrozole.

5. The method according to claim 1, further comprising determining that said human is not DQ2.2 seropositive where DQ 2.2 is not detected to be present in said human.

6. The method according to claim 1, wherein said human does not show significant elevation in alanine aminotransferase (ALT) and/or total bilirubin (TBL) after the administration of at least one dose of lapatinib, or a pharmaceutically acceptable salt or composition thereof.

Details for Patent 10,004,742

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Genentech HERCEPTIN trastuzumab VIAL; INTRAVENOUS 103792 1998-09-25 ⤷  Free Forever Trial Novartis AG (Basel, CH) 2039-02-26 RX Orphan search
Genentech Inc HERCEPTIN HYLECTA trastuzumab; hyaluronidase-oysk INJECTABLE;SUBCUTANEOUS 761106 2019-02-28 ⤷  Free Forever Trial Novartis AG (Basel, CH) 2039-02-26 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

International Patent Family for US Patent 10,004,742

Country Patent Number Estimated Expiration
South Africa 201201110 ⤷  Free Forever Trial
World Intellectual Property Organization (WIPO) 2011022633 ⤷  Free Forever Trial
United States of America 2012156200 ⤷  Free Forever Trial
United States of America 2015231137 ⤷  Free Forever Trial
United States of America 2017065590 ⤷  Free Forever Trial
United States of America 9539257 ⤷  Free Forever Trial
San Marino T201600296 ⤷  Free Forever Trial
>Country >Patent Number >Estimated Expiration

Make Better Decisions: Try a trial or see plans & pricing

Serving leading biopharmaceutical companies globally:

Merck
Medtronic
Express Scripts
Mallinckrodt
Moodys
Baxter

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.