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Last Updated: December 16, 2025

Biologic Drugs With Established Pharmaceutical Class: Asparagine-specific Enzyme

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Biologic Drugs With Established Pharmaceutical Class: Asparagine-specific Enzyme

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Patent Expiration
Servier Pharmaceuticals Llc	ONCASPAR	pegaspargase	Injection	103411	1994-02-01	⤷ Get Started Free	⤷ Get Started Free
Servier Pharmaceuticals Llc	ASPARLAS	calaspargase pegol-mknl	Injection	761102	2018-12-20	⤷ Get Started Free	⤷ Get Started Free
Jazz Pharmaceuticals Ireland Limited	RYLAZE	asparaginase erwinia chrysanthemi (recombinant)-rywn	Injection	761179	2021-06-30	⤷ Get Started Free	⤷ Get Started Free
Jazz Pharmaceuticals Ireland Limited	RYLAZE	asparaginase erwinia chrysanthemi (recombinant)-rywn	Injection	761179	2021-06-30	10,787,671	⤷ Get Started Free
Jazz Pharmaceuticals Ireland Limited	RYLAZE	asparaginase erwinia chrysanthemi (recombinant)-rywn	Injection	761179	2021-06-30	8,288,127	⤷ Get Started Free
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Patent Expiration

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