Serologic Response to SHINGRIX Vaccine in Patients With CLL and WM Treated With BTK Inhibitors
Active, not recruiting
University of Rochester
Early Phase 1
2019-02-01
The primary objective of the study is to assess the capability of a patient with Chronic
Lymphocytic Leukemia (CLL) or Waldenström Macroglobulinemia (WM) to generate an immune
response to the Shingrix vaccine under first-line BTK inhibitors.
This research is designed to determine if the adjuvanted recombinant glycoprotein E (gE)
herpes zoster (HZ) vaccine (Shingrix) has acceptable immunogenicity and safety in people who
have undergone allogeneic stem cell transplant (allo-SCT). Specifically, it will determine
the effect of the interval after transplantation on the immune response and if an additional
dose of vaccine is needed to improve the vaccine-induced responses.
This research is designed to determine if the adjuvanted recombinant glycoprotein E (gE)
herpes zoster (HZ) vaccine (Shingrix) has acceptable immunogenicity and safety in people who
have undergone allogeneic stem cell transplant (allo-SCT). Specifically, it will determine
the effect of the interval after transplantation on the immune response and if an additional
dose of vaccine is needed to improve the vaccine-induced responses.
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