The Safety and Efficacy of Clindamycin and Primaquine in the Treatment of Mild - Moderate Pneumocystis Carinii Pneumonia in Patients With AIDS
Completed
National Institute of Allergy and Infectious Diseases (NIAID)
N/A
1969-12-31
To determine the safety and effectiveness of clindamycin and primaquine in the treatment of
mild Pneumocystis carinii pneumonia (PCP) in AIDS patients.
As many as 80 percent of AIDS patients experience at least one episode of PCP and about
one-third of these patients have a recurrence of the disease. Drugs currently used for
treatment of acute PCP are toxic to the majority of AIDS patients. The combination of
clindamycin and primaquine reduces the numbers of PCP organisms in laboratory tests and in
animal studies. Both drugs can be given orally, concentrate in lung tissue, and have been
used safely in humans for treatment of other diseases. It is possible that the combination
may prove to be as good or better than standard therapy for PCP and side effects may be less.
Phase I Study of Human Von Willebrand Factor for Von Willebrand's Disease
Completed
University of North Carolina
Phase 1
1993-10-01
OBJECTIVES: I. Evaluate the effect of a new von Willebrand factor concentrate on bleeding
time, in vivo recovery, and circulating half-life of the infused factor in patients with von
Willebrand's disease.
II. Assess the safety of von Willebrand factor in these patients.
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