Treatment Of Dupuytren's Contracture With Collagenase Clostridium Histolyticum Injection (Xiapex)
This study will evaluate the impact of Xiapex treatment on the range of motion (ROM) of the
affected fingers and the patient and physician reported treatment satisfaction and disease
severity and their relation to ROM. Recovery to normal activities, recovery time (How long
overall, time to use hand, time to return to work or daily activities, amount of work or
daily activity time missed or reduced and affects on productivity and daily activities) will
be assessed via patient diary. Use of concomitant analgesic medications will be recorded and
total healthcare resource utilization (HCRU).
A Dose Escalation Study Using Collagenase Clostridium Histolyticum in the Treatment of Lipoma
Advance Biofactures Corporation
The purpose of this research is to evaluate the safest and most effective dose of a Food and
Drug Administration (FDA) approved drug (XIAFLEX) in the treatment of lipoma (fatty tumors of
varying sizes that occur commonly in the adult population). The fat in the lipoma is like
normal fat except that it is enclosed in a balloon-like structure which is made of collagen
(fibrous tissue). Treatment of the lipoma with an injection of XIAFLEX (a protein that breaks
down collagen fibers) may dissolve the collagen/fibrous strands thereby decreasing the size
of the lipoma or removing it.
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