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Last Updated: December 3, 2021

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CLINICAL TRIALS PROFILE FOR ANAKINRA

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All Clinical Trials for anakinra

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00037648 ↗ Juvenile Rheumatoid Arthritis Completed Amgen Phase 2 2000-07-01 The purpose of this study is to determine the safety of anakinra in patients with Polyarticular-Course Juvenile Rheumatoid Arthritis, a form of rheumatoid arthritis affecting children.
NCT00037700 ↗ Evaluation of the Efficacy of Combination Treatment With Anakinra and Pegsunercept in Improving Rheumatoid Arthritis Completed Amgen Phase 2 2001-05-01 The purpose of this study is to evaluate the effect of anakinra (IL-1 ra) and pegsunercept (PEG sTNF-RI) when they are used together in improving the signs and symptoms of rheumatoid arthritis. The study will also evaluate the safety of the combination treatment and its effect on slowing down bone and joint destruction due to rheumatoid arthritis. The results will be compared to the effect when only 1 single medication (anakinra or pegsunercept) is used.
NCT00069329 ↗ Anakinra to Treat Patients With Neonatal Onset Multisystem Inflammatory Disease Terminated National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) Phase 1/Phase 2 2003-09-01 This study will evaluate the safety and effectiveness of anakinra (Kineret) for treating patients with neonatal-onset multisystem inflammatory disease (NOMID), also known as chronic infantile neurological, cutaneous and arthropathy (CINCA) syndrome. This disease can cause rash, joint deformities, brain inflammation, eye problems, and learning difficulties. Immune suppressing medicines commonly used to treat other pediatric rheumatologic diseases do not suppress NOMID symptoms and, if used long-term and in high doses, can cause harmful side effects. Anakinra, approved by The Food and Drug Administration for treating rheumatoid arthritis in adults, blocks a substance called IL-1 that may be an important factor in causing the inflammation in NOMID.
NCT00094900 ↗ Interleukin-1 Trap to Treat Autoinflammatory Diseases Completed National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) Phase 2 2004-10-01 Autoinflammatory diseases are illnesses characterized by episodes of inflammation that, unlike autoimmune disorders, lack the production of high titer autoantibodies or antigen-specific T cells. There is growing genetic and clinical evidence that Interleukin-1 (IL-1) plays a pathogenic role in several of these diseases. This exploratory study aims to examine the utility of the experimental drug candidate, IL 1 Trap (Regeneron Pharmaceuticals, Inc.) in the treatment of adult subjects with the autoinflammatory disorders Neonatal Onset Multisystem Inflammatory Disease (NOMID), Muckle-Wells Syndrome (MWS), and Familial Cold Autoinflammatory Syndrome (FCAS), Familial Mediterranean Fever (FMF), and adult Still's disease. FMF is associated with mutations in pyrin encoding MEFV. NOMID, MWS and FCAS are associated with mutations in cryopyrin-encoding CIAS1. This pilot study is designed to address: 1) the utility of IL 1 Trap in the treatment of subjects with diseases known to respond to IL-1 blockade (NOMID/MWS/FCAS) as shown by response to treatment with anakinra [Kineret]; 2) the response to IL-1 blockade of subjects with Adult Still's disease and colchicine-resistant FMF once the efficacy of IL-1 Trap has been established in NOMID/MWS/FCAS subjects; and 3) the biochemistry and genetics of autoinflammatory diseases and IL-1 related inflammation. IL-1 Trap is a recombinant fusion protein with picomolar affinity for IL-1 and a half-life of approximately 7.5 days in humans. This agent is currently in Phase 2 clinical studies for the treatment of rheumatoid arthritis and initial studies have shown activity against clinical and biochemical indicators of inflammation. Compared with anakinra, this agent may exhibit improved dosing convenience, potential for fewer injection site reactions, and improved efficacy due to the extremely high affinity of IL-1Trap for its target. In this study, biochemical, genetic, and clinical correlates of autoinflammatory disease will initially be measured at baseline following a withdrawal of any TNF or IL-1 inhibitor medications where applicable. Subjects will receive a course of therapy with IL-1 Trap that is predicted to provide an estimated 3-4 weeks of anti-inflammatory activity. Clinical, biochemical, and genetic correlates of inflammation will be measured at appropriate intervals to ascertain response and to further elucidate disease mechanisms. Subjects will be eligible, based on clinical response, to enter a 1- year extension phase with IL-1 Trap. Those subjects who complete the 1-year extension phase, and maintain improved clinical and laboratory parameters compared to baseline values, may continue to receive study medication at their current dose until the study drug is commercially available. Investigator comment: This protocol (from the NIH standpoint) is a continuation of the ongoing protocol 05-AR-0014, with a new change in study sponsor, the NIH replacing Regeneron as sponsor. this protocol therefore still contains background and procedural information that refer to patients with FMF and FCAS and or MWS and Still's disease, however only patients with Still's disease will be newly enrolled from this point on, enrollment for the FCAS and or MWS patients has already been completed and it has been decided to not enroll any more FMF patients because the number of subjects is too low to reach reasonable conclusions, in addition it has been difficult to recruit patients that are eligible. The background section and study procedures have largely been left as in the currently IRB approved protocol.
NCT00110916 ↗ Treatment for Patients With Osteoarthritis (OA) of the Knee Completed Amgen Phase 2 2004-06-01 The purpose of this study is to evaluate the clinical response in subjects with symptomatic OA of the knee following a single 50 mg anakinra, 150 mg anakinra or placebo intra-articular (IA) injection.
NCT00111410 ↗ Evaluating the Effect of Anakinra (r-metHuIL-1ra) on Vaccine AntibodyResponse in Subjects With Rheumatoid Arthritis (RA) Completed Amgen Phase 4 1969-12-31 The purpose of this study is to estimate the effect of anakinra, 100 mg once daily (QD), on the development of an anti-tetanus antibody response in subjects with RA after vaccination with a tetanus and diphtheria toxoids injection. In addition, this study will evaluate the general safety profile of therapy with anakinra, 100 mg QD, in subjects with RA after vaccination with a tetanus and diphtheria toxoids injection.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for anakinra

Condition Name

Condition Name for anakinra
Intervention Trials
Rheumatoid Arthritis 10
Covid-19 7
Heart Failure 6
Inflammation 5
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Condition MeSH

Condition MeSH for anakinra
Intervention Trials
COVID-19 18
Arthritis 17
Arthritis, Rheumatoid 15
Syndrome 14
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Clinical Trial Locations for anakinra

Trials by Country

Trials by Country for anakinra
Location Trials
United States 148
Greece 19
France 16
Netherlands 12
Spain 11
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Trials by US State

Trials by US State for anakinra
Location Trials
Virginia 17
Texas 13
California 12
Maryland 11
New York 9
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Clinical Trial Progress for anakinra

Clinical Trial Phase

Clinical Trial Phase for anakinra
Clinical Trial Phase Trials
Phase 4 6
Phase 3 17
Phase 2/Phase 3 14
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Clinical Trial Status

Clinical Trial Status for anakinra
Clinical Trial Phase Trials
Completed 77
Recruiting 31
Terminated 17
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Clinical Trial Sponsors for anakinra

Sponsor Name

Sponsor Name for anakinra
Sponsor Trials
Virginia Commonwealth University 14
Radboud University 10
Swedish Orphan Biovitrum 9
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Sponsor Type

Sponsor Type for anakinra
Sponsor Trials
Other 213
Industry 37
NIH 36
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