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Last Updated: May 20, 2024

CLINICAL TRIALS PROFILE FOR SYLATRON


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All Clinical Trials for SYLATRON

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00018031 ↗ Peginterferon Alpha-2b And Ribavirin to Treat Hepatitis C in HIV-Infected Patients Completed National Institute of Allergy and Infectious Diseases (NIAID) Phase 2 2001-06-01 This study will evaluate the safety and effectiveness of combination therapy with peginterferon alfa-2b and ribavirin for treating hepatitis C virus (HCV) infection in HIV-infected patients. In studies of patients with hepatitis C alone, interferon alfa-2b plus ribavirin treatment eradicated the HCV in almost half the patients. Peginterferon alfa-2b is a compound that results from attaching a polyethylene glycol molecule to interferon alfa-2b. This compound stays in the blood longer than unmodified interferon alfa-2b, causing a higher blood concentration and thus maintaining activity against the hepatitis C virus. HIV-infected patients 21 years of age and older with chronic hepatitis C infection and a viral load greater than 2000 copies/mL may be eligible for this 2 1/2-year study. Candidates will be screened with blood and urine tests and possibly a liver biopsy, if a recent one is not available. The liver biopsy is done to determine the severity of liver disease. For this test, patients are admitted to the NIH Clinical Center for 1 to 2 days. A sedative is injected into an arm vein, the skin in the area over the biopsy site is numbed with a local anesthetic, and a needle is inserted rapidly into and out of the liver to obtain a small tissue sample. The patient remains in the hospital overnight for monitoring. A chest X-ray, electrocardiogram (EKG) and liver ultrasound are also done. Within 4 weeks of the screening tests, candidates who appear eligible for the study will have a physical examination, medical history and repeat blood tests. Women who can become pregnant will have serial pregnancy tests throughout the study. Patients who meet the study criteria and decide to participate will begin treatment with weekly injections under the skin of peginterferon alfa-2b and take ribavirin pills twice a day by mouth. In addition, patients will continue to take all other medications prescribed by their doctor. Clinic visits will be scheduled as follows: - Days 1, 3, 5, 7, 10 and 21 - Blood will be drawn for safety tests and to measure blood levels of HIV and HCV. - Weeks 2, 4, 8, 12, 16, 20, 24, 28, 32, 36, 40, 44, 52, 56 and 64 - Blood and urine tests will be done to determine the side effects of treatment and its effect on the HCV infection. - Week 48 or end of treatment - Treatment will stop after 48 weeks. At this time, or earlier for those who do not complete the 48 weeks, patients will return to the clinic for a routine test.
NCT00134030 ↗ Combination Chemotherapy, PEG-Interferon Alfa-2b, and Surgery in Treating Patients With Osteosarcoma Unknown status National Cancer Institute (NCI) Phase 3 2005-11-14 This randomized phase III trial is studying combination chemotherapy followed by surgery and two different combination chemotherapy regimens with or without PEG-interferon alfa-2b to compare how well they work in treating patients with osteosarcoma. Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more tumor cells. Biological therapies, such as PEG-interferon alfa-2b, may interfere with the growth of tumor cells. Giving combination chemotherapy before surgery may shrink the tumor so it can be removed. Giving combination chemotherapy together with PEG-interferon alfa-2b after surgery may kill any remaining tumor cells. It is not yet known whether giving combination therapy together with PEG-interferon alfa-2b is more effective than two different combination chemotherapy regimens alone after surgery in treating osteosarcoma.
NCT00134030 ↗ Combination Chemotherapy, PEG-Interferon Alfa-2b, and Surgery in Treating Patients With Osteosarcoma Unknown status University College London Hospitals Phase 3 2005-11-14 This randomized phase III trial is studying combination chemotherapy followed by surgery and two different combination chemotherapy regimens with or without PEG-interferon alfa-2b to compare how well they work in treating patients with osteosarcoma. Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more tumor cells. Biological therapies, such as PEG-interferon alfa-2b, may interfere with the growth of tumor cells. Giving combination chemotherapy before surgery may shrink the tumor so it can be removed. Giving combination chemotherapy together with PEG-interferon alfa-2b after surgery may kill any remaining tumor cells. It is not yet known whether giving combination therapy together with PEG-interferon alfa-2b is more effective than two different combination chemotherapy regimens alone after surgery in treating osteosarcoma.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for SYLATRON

Condition Name

Condition Name for SYLATRON
Intervention Trials
Melanoma 2
Advanced Cholangiocarcinoma 1
Hepatitis C 1
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Condition MeSH

Condition MeSH for SYLATRON
Intervention Trials
Melanoma 2
Osteosarcoma 1
Infections 1
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Clinical Trial Locations for SYLATRON

Trials by Country

Trials by Country for SYLATRON
Location Trials
United States 49
Canada 9
Australia 5
New Zealand 2
Puerto Rico 1
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Trials by US State

Trials by US State for SYLATRON
Location Trials
Florida 2
Maryland 2
District of Columbia 2
Pennsylvania 2
Connecticut 1
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Clinical Trial Progress for SYLATRON

Clinical Trial Phase

Clinical Trial Phase for SYLATRON
Clinical Trial Phase Trials
Phase 3 1
Phase 2 2
Phase 1 3
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Clinical Trial Status

Clinical Trial Status for SYLATRON
Clinical Trial Phase Trials
Completed 4
Terminated 1
Unknown status 1
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Clinical Trial Sponsors for SYLATRON

Sponsor Name

Sponsor Name for SYLATRON
Sponsor Trials
Merck Sharp & Dohme Corp. 4
Georgetown University 2
Roswell Park Cancer Institute 1
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Sponsor Type

Sponsor Type for SYLATRON
Sponsor Trials
Other 12
Industry 4
NIH 2
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